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About the Role
AbbVie's CAR-T Biology team is seeking a Scientist II to support the development of in vivo CAR-T platforms from concept through preclinical development, working at the intersection of synthetic biology and immune modulation. The role includes designing CAR constructs, executing advanced cell-based assays, and collaborating with cross-functional teams to generate high-quality data that support pipeline programs.
Responsibilities
- Design and execute in vitro assays to evaluate CAR-T biology, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping.
- Independently establish, track, and deliver on project milestones and experimental timelines, ensuring alignment with program objectives and organizational priorities, while adapting to evolving scientific needs.
- Organize, analyze, and synthesize complex scientific data, and effectively communicate experimental strategies, results, and interpretations to internal and external stakeholders through clear and impactful presentations and scientific reports.
- Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).
Requirements
- BS, or equivalent education, with typically 7 or more years of experience; or MS, or equivalent education, with typically 5 or more years of experience, in immunology, cell and molecular biology, or related field.
- Demonstrated ability to independently design, perform, and interpret key experiments to address scientific questions.
- Proven capacity to quickly learn and apply new laboratory techniques.
- Able to manage multiple tasks efficiently while meeting deadlines.
- Strong skills in scientific writing and verbal communication.
- Previous experience in chimeric antigen receptor (CAR) construct design, CAR-T production, and T cell function evaluation.
- Deep expertise in primary T cell isolation, activation, transduction, T cell cytotoxicity, proliferation, cytokine profiling, multi-color flow cytometry, and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.
- Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is a plus.
Skills
- CAR-T biology
- T-cell functional assays
- Therapeutic development
- Synthetic biology
- Immune modulation
- CAR construct design
- Cell-based assays
- Scientific data analysis
- Scientific writing
- Verbal communication
- Primary T cell isolation
- T cell activation
- T cell transduction
- T cell cytotoxicity
- T cell proliferation
- Cytokine profiling
- Multi-color flow cytometry
- Immunological assays
- ELISA
- Luminex
- Cell-based in vitro assay development
- Semi-automated liquid handling systems
Location
- South San Francisco
Work Type
- Full-time
Experience Level
- Scientist II
- 7+ years with BS
- 5+ years with MS
Education Level
- BS or equivalent
- MS or equivalent
Salary/Compensations
- USD 84500 - USD 162000 - yearly
Benefits
- Paid time off (vacation, holidays, sick)
- Medical/dental/vision insurance
- 401(k)
- Short-term incentive programs
About the Company
- AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.
- We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio.
- For more information about AbbVie, please visit us at www.abbvie.com.
- Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
Equal Opportunity
- AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.
- Equal Opportunity Employer/Veterans/Disabled.
- US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
- US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html