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About the Role

IDEAYA is a precision medicine oncology company dedicated to discovering, developing, and commercializing transformative cancer therapies. We are seeking an accomplished Senior Principal Research Scientist in Computational Chemistry with significant pharmaceutical industry experience to join our multidisciplinary small molecule drug discovery organization. This is a senior individual contributor role for a highly experienced computational chemist with a strong track record of advancing pharmaceutical discovery programs through hands-on scientific impact.

Responsibilities

Lead structure-based drug design meetings with medicinal chemists and provide senior-level, hands-on drug design and computational chemistry support to small molecule drug discovery project teams
Contribute to programs from target identification through lead optimization and drug candidate selection
Apply structure-, ligand-, and fragment-based modeling to guide medicinal chemistry design
Use molecular dynamics, free energy methods, quantum chemistry, and cheminformatics to address complex design and prioritization questions
Translate computational analyses into clear, actionable compound design recommendations
Serve as a highly experienced computational contributor and scientific advisor within project teams
Mentor and coach other scientists in structure-based drug design through technical guidance and scientific discussion
Evaluate new computational methods, tools, and workflows and apply them when they add clear value
Maintain scientific rigor, reproducibility, and best practices in an industry drug discovery environment

Requirements

PhD in Computational Chemistry or a related discipline with 9+ years of pharmaceutical or biotechnology industry experience
Strong understanding of small molecule drug discovery and medicinal chemistry principles
Demonstrated expertise in structure-, ligand-, and fragment-based drug discovery
Expertise in free energy perturbation, molecular dynamics, quantum mechanics, cheminformatics, and ligand affinity estimation methods
Proven ability to independently deliver computational work that influences medicinal chemistry decisions and project outcomes
Ability to manage priorities across multiple discovery programs
Excellent oral and written communication skills
Experience applying machine learning or AI methods to molecular design, property prediction, or compound prioritization
Experience with Schrödinger modeling software and others (e.g., MOE, OpenEye)
Programming, scripting, statistics, and data analysis experience applied to drug discovery
Experience working on challenging target classes, including protein–protein interactions and allosteric pockets
Track record of contributing to discovery programs that advance high-quality small molecule drug candidates
All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct.
Employees must demonstrate good judgement and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or Company policy through appropriate channels.

Skills

Computational Chemistry
Small molecule drug discovery
Medicinal chemistry
Structure-based drug design
Ligand-based modeling
Fragment-based modeling
Molecular dynamics
Free energy methods
Quantum chemistry
Cheminformatics
Machine learning
AI methods
Schrödinger modeling software
MOE
OpenEye
Programming
Scripting
Statistics
Data analysis
Protein–protein interactions
Allosteric pockets

Location

South San Francisco, CA

Work Type

Onsite (four days per week)
Hybrid

Experience Level

Senior Principal
9+ years of pharmaceutical or biotechnology industry experience

Education Level

PhD in Computational Chemistry or a related discipline

Salary/Compensations

$196,000 - $242,000

Benefits

Medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents)
401k
ESPP
Wellness programs
Merit-based salary increases
Company discretionary short-term incentive plan participation
Company discretionary stock option awards

About the Company

IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer.
Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease.
We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications.
Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer.
When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients.
We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA.
We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.
For more information, please see www.ideayabio.com.

Equal Opportunity

The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.
IDEAYA is an equal opportunity employer.
In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status.
EOE/AA/Vets.