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About the Role
The South San Francisco DMPK organization is seeking a Senior Principal Scientist to provide scientific leadership for drug conjugate discovery and development programs, support strategic portfolio decisions, and advance DMPK capabilities for emerging modalities. This role involves partnering with various scientific and development teams to enable data-driven decision-making throughout the drug development lifecycle.
Responsibilities
- Provide scientific leadership for DMPK strategy supporting drug conjugates and related novel modalities.
- Represent DMPK on cross-functional discovery and development teams, integrating ADME, PK, PK/PD, bioanalytical, pharmacology, toxicology, and clinical pharmacology perspectives to guide program decisions.
- Lead the development and implementation of fit-for-purpose DMPK screening funnels and translational plans to support lead optimization, candidate selection, human dose projection, and regulatory packages.
- Provide scientific oversight for LM ADME experimentation strategy and capabilities.
- Contribute to portfolio management by identifying DMPK-related opportunities, liabilities, resource needs, and decision points across programs.
- Author, review, and present high-quality scientific documents, nonclinical packages as part of regulatory submissions, project updates, and decision-making materials for internal and external stakeholders.
- Directly manage and develop a group of investigators and scientific experts, setting clear scientific expectations, enabling effective prioritization and execution, and fostering continued growth of technical and leadership capabilities.
- Monitor external scientific advances in conjugates, ADME, translational PK/PD, bioanalysis, and emerging modalities, and integrate relevant innovations into internal strategy.
- Collaborate effectively with internal teams, external partners, and contract research organizations to ensure efficient delivery of high-impact DMPK data packages.
Requirements
- Master's (with 15+ years) or Ph.D. (with 12+ years) in pharmacokinetics, drug metabolism, pharmaceutical sciences, pharmacology, bioengineering, chemistry, biochemistry, biological sciences, or a related discipline with significant experience in DMPK, ADME, translational pharmacology, or biologics/conjugate drug development.
- Extensive experience in DMPK, ADME, pharmacokinetics, translational science, or related disciplines, with a strong record of scientific impact in discovery and/or development programs.
- Deep scientific expertise in ADME, PK, PK/PD, bioanalysis, and translational interpretation, with demonstrated ability to apply these disciplines to complex modalities such as drug conjugates, biologics, or other novel therapeutic platforms.
- Proven ability to design, interpret, and integrate in vitro and in vivo data to enable program progression, candidate selection, human PK projection, dose selection, and regulatory strategy.
- Demonstrated experience serving as a DMPK representative or scientific leader on cross-functional project teams and influencing program strategy through clear, data-driven recommendations.
- Strong understanding of nonclinical-to-clinical translation, IND-enabling requirements, and the role of DMPK data in regulatory submissions and clinical development planning.
- Excellent written and verbal communication skills, with the ability to present complex scientific concepts clearly to technical, cross-functional, and senior leadership audiences.
- Strong collaboration, mentoring, and talent development skills, with a commitment to building an inclusive, high-performing scientific culture.
- Track record of scientific leadership, including shaping strategy, solving complex problems, leading matrixed teams, and driving decisions in a fast-paced portfolio environment.
- Experience with small molecule ADME drug discovery applicable to conjugate discovery and development.
- Familiarity with model-informed drug discovery and development approaches, including translational PK/PD, PBPK, population PK, exposure-response, or human dose projection.
- Demonstrated external scientific visibility through publications, conference presentations, consortia participation, or cross-industry engagement.
Skills
- ADME
- Antibody Drug Conjugates (ADC)
- Biologics
- DMPK
- Drug Metabolism
- In Vitro Assays
- People Management
- Pharmacodynamics
- Pharmacokinetics
- Pharmacology
- Portfolio Management
- Scientific Leadership
- Talent Development
- Translational Pharmacokinetics and Pharmacodynamics (PKPD)
Location
- South San Francisco
Work Type
- Regular
- Domestic/International Relocation
- VISA Sponsorship
- 10% Travel
Experience Level
- Senior Principal Scientist
- 15+ years (Master's)
- 12+ years (Ph.D.)
Education Level
- Master's Degree
- Ph.D.
Salary/Compensations
- $194,100.00 - $305,600.00
Benefits
- Annual bonus and long-term incentive
- Medical, dental, vision healthcare and other insurance benefits (for employee and family)
- Retirement benefits, including 401(k)
- Paid holidays, vacation, and compassionate and sick days
About the Company
- Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, is committed to inclusion and embraces the value of bringing together talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
Equal Opportunity
- As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
- San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
- Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.