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About the Role

This is an execution-first role focused on reliably operating a fleet of 16 benchtop bioreactors. The goal is to make large-scale reactor operation routine through flawless preparation, clean technique, and repeatable operation, while independently troubleshooting equipment and controls.

Responsibilities

• Operating the full 16-reactor fleet: twelve 300 mL and four 3 L mammalian-cell-culture bioreactors, often in parallel and on shared run schedules.
• Assembling vessels, tubing, probes, spargers and single-use components; leak-checking assemblies and staging everything required for each run.
• Cleaning, sterilising or autoclaving, reassembling and turning vessels around to a defined daily rhythm so the next run starts on time.
• Executing approved run plans exactly: inoculation, media and feed additions, set-point changes, sampling, harvest and sample hand-off.
• Calibrating and maintaining pH, dissolved oxygen and temperature probes, and checking gas, agitation, pump and alarm functions before use.
• Troubleshooting controls and cascade behaviour independently — including DO, gas-mix, agitation, pump and sensor issues — and knowing when a problem genuinely needs escalation.
• Protecting the sterile boundary throughout every run; recognising contamination early and leading the immediate isolation, clean-down and recovery response.
• Processing and labelling samples consistently, maintaining chain of custody and ensuring scientists can trust the resulting data.
• Completing electronic records, run logs, deviations and equipment checks in real time, and keeping consumables and work areas inspection-ready.

Requirements

• At least three years of hands-on industry experience operating mammalian cell-culture bioreactors. Academic-only experience is not sufficient.
• Demonstrated experience assembling, sterilising, inoculating, sampling, feeding, harvesting and turning around benchtop bioreactors.
• Working knowledge of bioreactor controls and cascades; ability to diagnose common probe, gas, agitation, pump and alarm problems independently.
• Excellent aseptic technique and a practical understanding of contamination prevention, detection and response.
• Strong operational discipline: prepare ahead, follow approved procedures, document as you go and raise exceptions early.
• Able to work a consistent full-time schedule that includes at least one weekend day (e.g., Sunday to Thursday or Tuesday to Saturday).
• The right to work in Australia.
• Ability to work on site in Alexandria, Sydney.

Skills

• Mammalian cell-culture bioreactor operation
• Bioreactor assembly and sterilization
• Aseptic technique
• Bioreactor controls and cascades
• Contamination prevention, detection, and response
• Electronic record keeping
• Sample processing and labeling
• Equipment troubleshooting
• Parallel bioreactor systems operation (nice to have)
• CHO cell culture (nice to have)
• Antibody production (nice to have)
• GMP/GLP environment experience (nice to have)
• Electronic batch records (nice to have)
• ELNs (nice to have)
• LIMS (nice to have)
• Equipment maintenance (nice to have)
• Process control (nice to have)

Location

• Alexandria, Sydney, Australia

Work Type

• On-site
• Full-time

Experience Level

• Experienced operator

Salary/Compensations

• AUD $85,000–$100,000 base salary

Benefits

• Superannuation
• Early-stage equity

About the Company

• Airtree is advertising this role on behalf of one of our portfolio companies, who are currently in stealth mode.
• The company's mission is to make biologics radically cheaper so modern medicine reaches more people and animals.
• They are building factories to achieve a 20–50x cost reduction at scale for drug substance manufacturing.
• The company is founded by individuals who previously scaled a biomanufacturing company by industrializing mammalian cell culture.
• They operate with a small team, fast cycles, and a flat structure.
• Values include high standards, direct communication, and system improvement.