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About the Role

Research Informatics is responsible for the scientific data platforms and internal software that underpin the full research and development pipeline at Denali Therapeutics. This function owns the strategy, implementation, and ongoing support of the digital tools that enable scientists to register molecular entities and to track, analyze, and document associated experimental data across the full lifecycle. The Director of Research Informatics will lead this function, serving as the strategic and operational owner of our scientific data platforms, including Benchling, Dotmatics, and our internal software and AI tool integration. This is a hands-on leadership role where the Director will set technical direction and make software architecture and design-space decisions.

Responsibilities

Owns the strategy, roadmap, and operational delivery of Research Informatics, including Benchling, Dotmatics, internal software systems, and AI integration.
Leads and grows a team responsible for platform support, configuration, validation, and continuous improvement across Discovery, Development, and Technical Operations.
Partners with scientists and lab operations leads to translate business and scientific requirements into scalable, well-engineered platform solutions.
Serves as subject matter expert on ELN capabilities and experiment data workflows, advising on platform selection and integration strategy.
Communicates platform strategy, status, and risk clearly to senior stakeholders.
Engages hands-on in configuration and platform build work, alongside strategic oversight.
Drives vendor relationships and manages platform migrations, escalations, and contract performance.
Explores and integrates next-generation, AI-driven experiment capture concepts.
Owns roadmap prioritization and backlog decisions, balancing input from scientific, engineering, and IT stakeholders.
Leads direct report(s) through annual goal setting, growth planning, adherence to company policies, maintains training compliance, and provides ongoing feedback.

Requirements

Typically requires a Bachelor's degree in a technical field (computer science, data science, engineering, or related); advanced degree preferred.
Typically requires 10+ years building and delivering software solutions, including 7+ years in pharma, biotech, or life sciences supporting laboratory informatics or scientific platforms.
Typically requires 8+ years of people management experience, including building and growing engineering teams.
Hands-on expertise with scientific data platforms (e.g., Benchling, Dotmatics) and experience leading ELN/registry migrations preferred.
Experience partnering with enterprise IT on security, licensing, and infrastructure, and familiarity applying AI/ML workflows to biological or chemical data, preferred.

Skills

Benchling
Dotmatics
Electronic Laboratory Notebook (ELN)
AI/ML workflows
scientific data platforms
laboratory informatics

Location

Remote

Work Type

Full-time

Experience Level

Director
10+ years building and delivering software solutions
7+ years in pharma, biotech, or life sciences supporting laboratory informatics or scientific platforms
8+ years of people management experience

Education Level

Bachelor's degree in a technical field (computer science, data science, engineering, or related)
Advanced degree preferred

Salary/Compensations

$204,000.00 to $265,000.00

Benefits

401k
Healthcare coverage
ESPP
Broad range of other benefits

About the Company

Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine.
Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

Equal Opportunity

Denali is committed to its core company value of unity by creating a diverse and inclusive environment.
We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.