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About the Role
Excelsior Sciences of New York is transforming small molecule therapeutic drug discovery using modular chemistry and automation. This laboratory-based role involves profiling new leads and advancing novel small molecule therapeutics by operating High Throughput Automated Screening Systems and performing LC/MS analysis for small molecule ADME.
Responsibilities
- Operate and maintain Mass Spectrometers, ensuring optimal performance and troubleshooting issues.
- Follow SOPs for data analysis, including peak picking, mass spectral deconvolution, and support interpretation of results.
- Prepare samples for high throughput LC/MS analysis, ensuring compatibility with MS systems.
- Carry out routine and preventative maintenance and minor repairs, coordinate more complex service, of analytical equipment to ensure uninterrupted lab activities.
- Prepare and maintain inventory of reagents and consumables and perform ADME assays on automation platform.
- Document study protocols/findings and contribute to study report authorship.
- Use electronic documentation of analytical results, methods, and instrument performance.
- Communicate project status and issues to management and other stakeholders.
- Ensure compliance with laboratory safety protocols and regulatory standards.
Requirements
- Bachelor's or Master's degree in Analytical/Pharmaceutical Sciences, ADME, or a related field.
- 1-2 years of experience working with LC-MS systems (preferably Agilent systems) ideally with applications for ADME assays.
- Knowledge in LC-MS software and data analysis tools.
- Demonstrated analytical and problem-solving skills.
- Ability to work independently and collaboratively in a team environment.
- Strong communication and interpersonal skills.
- Experience with liquid handlers or automation.
- Working knowledge of software tools from Agilent (OpenLab, MassHunter) and Virscidian.
- Expertise in small molecule screening and analysis.
- Experience in data management and analysis.
- Experience with writing scientific reports and presenting data.
Skills
- LC/MS
- Small molecule ADME analysis
- Mass Spectrometry
- LC-MS software
- Data analysis tools
- Analytical skills
- Problem-solving skills
- Communication skills
- Interpersonal skills
- Liquid handlers
- Automation
- Agilent OpenLab
- Agilent MassHunter
- Virscidian
- Small molecule screening
- Data management
- Scientific report writing
- Data presentation
Location
- U.S.-based
Work Type
- Laboratory-based
- Full-time
Experience Level
- 1-2 years
Education Level
- Bachelor's degree
- Master's degree
Salary/Compensations
- $80,000 - $120,000 per year
Benefits
- Health insurance
- Paid time off
About the Company
- Excelsior Sciences of New York is transforming small molecule therapeutic drug discovery with the use of modular chemistry, to make better medicines fast.
- Excelsior's modular approach leverages smart blocks as the foundation of drug design and synthesis.
- Our smart blocks and proprietary methodologies enable chemistry that machines can do, rather than building machines that attempt to do chemistry as it is practiced today.
- By coupling our automated synthesis and testing, we can reduce the design-make-test-analyze cycle to two weeks.
- This rapid generation of high-quality data allows us to fully leverage AI/ML to create closed learning loops and conduct multiparameter optimization, resulting in better medicines, fast.
- Excelsior's operations are fully U.S.-based, as our automated approach enables us to onshore integrated drug discovery.
Equal Opportunity
- Excelsior Sciences of New York Is an equal opportunity employer (EEO).
- We provide equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.