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About the Role

TBC is hiring a Director of Biology to lead our San Francisco laboratory and manage the biology team. You will be responsible for the scientific quality, experimental throughput, and operational performance of the wet lab, leading scientists and research staff across various experimental areas. This senior leadership role requires strong scientific judgment, people management, and operational execution to build a reliable, reproducible, and scalable biological platform.

Responsibilities

Lead the SF biology team, including managing, mentoring, and developing staff.
Set team priorities, allocate resources, and ensure high-quality execution across experimental programs.
Support recruiting, onboarding, performance management, and professional development for the biology organization.
Build a culture centered on scientific rigor, documentation, collaboration, safety, accountability, and speed.
Oversee day-to-day wet-lab operations, including equipment, supplies, inventory, purchasing, and vendor relationships.
Ensure facilities, equipment, and workflows support current research priorities and future growth.
Lead planning for laboratory expansion, new equipment, maintenance, process improvements, and additional experimental capacity.
Identify operational risks and implement systems for safe, consistent, and efficient laboratory operation.
Oversee neuronal culture systems, tissue preparation, and experimental workflows involving living neural networks.
Maintain and improve culture viability, consistency, reproducibility, and experimental throughput.
Establish clear quality-control standards for biological preparations and experimental readiness.
Partner with scientists across disciplines to design stimulation, recording, and analysis workflows.
Lead experimental programs involving multi-electrode array systems for neural stimulation and recording.
Ensure the collection of high-quality electrophysiological data with appropriate documentation, quality control, and data management.
Develop repeatable experimental protocols that support rapid iteration across biology, computational neuroscience, and AI.
Connect biological measurements to model performance and company milestones.
Own laboratory safety, quality, and regulatory standards, including GLP-aligned practices, biological safety procedures, and standard operating procedures.
Ensure experimental protocols, training records, and laboratory documentation are complete, accurate, and current.
Oversee animal research support and compliance with approved IACUC protocols.
Maintain appropriate practices for equipment use, biological materials, tissue handling, waste disposal, and experimental recordkeeping.
Work closely with AI, computational neuroscience, engineering, product, and leadership teams to align biology priorities with company objectives.
Translate experimental results, risks, and resource requirements into clear recommendations for the technical roadmap.
Help define biological milestones and determine which experimental programs should receive additional investment.
Serve as a senior scientific and operational leader as TBC scales biology into a repeatable platform.

Requirements

B.S., M.S. or Ph.D. in Neuroscience, Cell Biology, Bioengineering or a related field.
At least seven years of relevant wet-lab experience.
Two or more years managing scientists, research associates or laboratory teams.
Experience with mammalian cell culture, primary neuronal culture or neural tissue systems.
Strong understanding of laboratory operations, equipment management, biological safety, documentation, and quality systems.
Experience managing vendors, inventory, purchasing, and complex experimental workflows.
Demonstrated ability to lead interdisciplinary scientific teams and manage multiple priorities.
Strong written and verbal communication skills.
Ability to work full-time on site in TBC’s San Francisco laboratory.

Skills

Mammalian cell culture
Primary neuronal culture
Neural tissue systems
Laboratory operations
Equipment management
Biological safety
Documentation
Quality systems
Vendor management
Inventory management
Purchasing
Experimental workflow management
Interdisciplinary team leadership
Multi-electrode array systems
Electrophysiology
Animal research
GLP standards
Immunoassays
Immunohistochemistry
Viral transduction
Chemogenetic methods
Biotechnology
Neurotechnology
AI-adjacent research

Location

San Francisco

Work Type

On-site
Full-time

Experience Level

Senior leadership
7+ years wet-lab experience
2+ years management experience

Education Level

B.S.
M.S.
Ph.D.

About the Company

The Biological Computing Co. (TBC) is an applied biological computing company that uses real neurons to improve AI models.
TBC studies how biological neural networks process information, extracts useful computational principles, and translates those insights into software that makes modern AI models better, faster, and more efficient.
The Algorithm Discovery Platform brings together biology, computational neuroscience, AI research, and software engineering to develop new algorithms, architectures, and neurally-optimized software for generative video and next-generation AI infrastructure.
TBC is commercializing neurally optimized models that run on conventional GPU and cloud infrastructure.
Longer term, TBC is building toward real-time biological compute, where real neurons operate alongside silicon as part of the compute stack.
The interdisciplinary team includes researchers and engineers with experience at Apple, Johns Hopkins, Meta, MIT, Stanford, and other leading institutions.