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About the Role
We are a vibrant and mission-driven team seeking ambitious, high-integrity individuals who want to become dramatically better. Capable Labs offers an environment where you can gain clarity on open-ended problems, take ownership, and drive important work forward, surrounded by a team that cares intensely about the work and provides close feedback.
Responsibilities
- Work a dedicated night-shift schedule, running chemistry workflows overnight so compounds are ready for characterization, testing, or handoff the next day.
- Execute overnight peptide synthesis workflows, including resin loading, coupling and deprotection cycles, cleavage, purification, analytical characterization, and sample preparation for testing.
- Run microwave-assisted solid-phase peptide synthesis during night-shift hours, support routine synthesizer maintenance, and help troubleshoot failed couplings, low crude purity, side products, cleavage issues, and instrument downtime.
- Purify and characterize peptide candidates using analytical HPLC, prep HPLC, LC-MS, and related methods; record identity, purity, yield, and batch-level QC data for morning handoff.
- Prepare compounds for in vitro and in vivo testing, maintain accurate experimental records, and communicate overnight synthesis results, issues, and timelines clearly to the day team.
Requirements
- Specifically looking for or open to a night-shift lab role.
- Comfortable working overnight hours, operating independently during quieter lab periods, and handing off clean, well-documented work to the day team.
- Hands-on chemistry or biochemistry lab experience and strong experimental discipline.
- Ability to learn quickly and care about the quality of the result.
- Proactive and reliable when issues arise.
- Ability to document clearly, communicate early, and help troubleshoot toward a clean result when problems occur.
Skills
- Peptide synthesis
- Resin loading
- Coupling and deprotection cycles
- Cleavage
- Purification
- Analytical characterization
- Sample preparation
- Microwave-assisted solid-phase peptide synthesis
- Synthesizer maintenance
- Troubleshooting
- Analytical HPLC
- Prep HPLC
- LC-MS
- Experimental record keeping
- Clear communication
Location
- San Francisco
Work Type
- Night-shift
- Full-time
Experience Level
- Early-stage environment experience preferred
- Experience level not explicitly defined but compensation depends on scope of impact
Education Level
- Education path matters less than ability to learn quickly
Salary/Compensations
- $140,000-$180,000
- Equity options with an implied current value of approximately $50,000-$200,000 before exercise cost, taxes, dilution, and liquidity risk.
Benefits
- $500+ monthly wellness budget
- 100% covered medical, dental, and vision coverage
- HSA, FSA, and 401K plans
- Visa sponsorship support
About the Company
- We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
- We value speed and rigor, coupled with excitement, drive, and a strong work ethic.
- Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.
- We believe excellent work should be met with meaningful reward, ownership, and trust.
- Responsibility is earned through contribution, not title alone.
- Our process is fast, transparent, and personal.
- Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.
Equal Opportunity
- We care about getting to know the person behind the application.
- Curious but not sure? Apply anyway. It takes 5 minutes, and you do not need to be actively job searching to start a conversation.
- Some of the best people do not map perfectly to a job description. If this sounds like a place where you could do important work, we would like to hear from you.
- If someone exceptional comes to mind, send them our way. We read every referral carefully, and if your referral joins Capable, we’ll send you a thank-you bonus.