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About the Role

The Landau Lab at the New York Genome Center/Weill Cornell Medicine is seeking a motivated experimental scientist to join their interdisciplinary team studying somatic evolution, cancer genomics, and epigenomics. The role involves performing, optimizing, and scaling experimental workflows for next-generation sequencing, single-cell genomics, and functional genomics, contributing to both technology development and biological research.

Responsibilities

Perform molecular biology workflows associated with DNA and RNA sequencing, including nucleic acid extraction, sample quality control, amplification, library preparation, purification, quantification, and sequencing submission.
Process cultured cells, primary specimens, tissues, and cell or nuclei suspensions for genomic and functional assays.
Perform single-cell and multi-omic workflows, including single-cell RNA sequencing, single-cell ATAC sequencing, combined DNA and RNA profiling, targeted genotyping, and single-cell whole-genome sequencing.
Contribute to the development, optimization, miniaturization, and scaling of novel experimental methods for single-cell genomics, epigenomics, and cell-free DNA analysis.
Assist with the implementation of high-throughput and automated laboratory workflows, including liquid-handling and plate-based processes.
Collaborate with experimental and computational researchers to plan studies, coordinate sample processing, and ensure that generated data address the relevant biological questions.
Maintain detailed, accurate, and timely records in electronic laboratory notebooks, sample-tracking systems, and project databases.
Communicate experimental progress, results, and technical issues clearly during project meetings.
Maintain laboratory organization, reagent inventories, equipment, and appropriate safety practices.
Support multiple concurrent research and technology-development projects.
Perform other responsibilities as assigned.

Requirements

Bachelor’s degree in molecular biology, biotechnology, biochemistry, genetics, genomics, biomedical engineering, or a related discipline.
Prior hands-on experience in an academic, biotechnology, or clinical molecular biology laboratory.
Experience with fundamental molecular biology techniques, including DNA and RNA handling, PCR, nucleic acid purification, quantification, and gel or fragment analysis.
Strong organizational and documentation skills, including the ability to manage multiple samples and experiments simultaneously.
Ability to follow established protocols while also identifying opportunities for troubleshooting and improvement.
Strong written and verbal communication skills.
Demonstrated reliability, initiative, curiosity, and eagerness to learn new technologies.

Skills

Molecular biology
DNA and RNA sequencing
Single-cell genomics
Functional genomics
Next-generation sequencing library preparation
Cell-free DNA analysis
High-throughput laboratory workflows
Liquid-handling
Plate-based processes
Sequencing quality control
R
Python
Command line

Location

Weill Cornell Medicine
New York Genome Center

Work Type

Wet-laboratory
Full-time

Experience Level

Early-career scientist
One or more years of experience with next-generation sequencing library preparation (preferred)

Education Level

Bachelor’s degree
Master’s degree (preferred)

Salary/Compensations

$46,118.80 - $58,895.20

About the Company

The Landau Lab develops and applies innovative genomic technologies to study the fundamental principles of somatic evolution in cancer, aging, and human disease. Our research integrates molecular biology, functional genomics, single-cell analysis, computational genetics, and clinical investigation.
The laboratory has pioneered approaches for single-cell multi-omic profiling, lineage tracing, analysis of clonal evolution, and cell-free DNA characterization. Our work spans the development of new experimental technologies and their application to biological and translational questions using patient-derived specimens, model systems, and large-scale genomic datasets.
Dr. Dan Landau maintains a joint laboratory between Weill Cornell Medicine and the New York Genome Center, providing a highly collaborative environment at the interface of technology development, computational biology, and translational genomics.

Equal Opportunity

We are committed to fostering a workplace environment that is welcoming and fair to all, ensuring that every employee has the opportunity to thrive. We believe that bringing together individuals with diverse backgrounds, experiences, and perspectives leads to greater collaboration, innovation, and discovery. Valuing and supporting each employee in reaching their full potential strengthens our organization and enhances our collective success. We recognize that creating an environment where all employees feel valued and included requires sustained effort and dedication from the entire organization.
The New York Genome Center is a VEVRAA Federal Contractor. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of race, creed, color, gender, religion, national origin, sexual orientation, age, disability, genetic predisposition or carrier status, protected veteran or military status, domestic violence victim status, partnership status, caregiver status, alienage or citizenship status, marital status, or any other characteristic protected by applicable law. NYGC takes affirmative action in support of its policy to hire and advance in employment individuals who are protected veterans and individuals with disabilities.