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About the Role

General Proximity is seeking an experienced DMPK expert to lead their drug metabolism and pharmacokinetics function. This is a hands-on, high-impact role focused on designing and executing DMPK studies, interpreting data, and contributing to cross-functional teams to advance programs from lead optimization through IND. The role is ideal for a scientist with several years of DMPK experience looking for greater ownership in a mission-driven company at the forefront of induced proximity medicine.

Responsibilities

• Design, execute, and interpret in vitro ADME studies, including metabolic stability, CYP inhibition/induction, plasma protein binding, permeability, solubility, and transporter assays.
• Contribute to in vitro–in vivo correlation (IVIVC) analyses.
• Interpret metabolic soft spot and MetID data, providing guidance to medicinal chemistry teams.
• Support CRO relationships for outsourced ADME studies, including scientific oversight and data quality review.
• Support bioanalytical activities, including CRO-performed LC-MS/MS method development.
• Help ensure GLP-compliant bioanalytical practices and monitor regulated bioanalysis timelines and data quality.
• Contribute to fit-for-purpose bioanalytical approaches for induced proximity molecules.
• Design and support in vivo PK studies across species, including study design, data interpretation, and cross-program learnings.
• Perform high-quality PK data analysis (NCA and compartmental) using Phoenix WinNonlin or equivalent.
• Integrate PK data with pharmacology and toxicology readouts.
• Coordinate with CROs for in vivo studies, tracking scope, timelines, and scientific deliverables.
• Perform PK/PD modeling and simulation, including PBPK modeling and allometric scaling for human PK prediction.
• Apply quantitative pharmacology approaches to support translational decision-making, FIH dose selection, and clinical dose range prediction.
• Use modeling and simulation to inform go/no-go decisions and communicate DMPK findings.
• Present DMPK modeling results in cross-functional project team meetings.
• Support DMPK execution for IND-enabling programs, including study design, drafting study reports, and data package delivery.
• Contribute to DMPK sections of IND and CTA submissions; author and review relevant study reports and document sections.
• Support preparation of DMPK materials for interactions with regulatory agencies.
• Maintain working knowledge of current regulatory guidance (DDI, MIST, bioanalytical method validation, ICH M9/M10) and apply evolving standards.
• Contribute to DMPK team goals and priorities.
• Serve as an active member of cross-functional project teams, contributing DMPK input to program planning and decision-making.
• Support DMPK input for scientific evaluations and collaborations.
• Support clinical pharmacology activities as programs advance toward IND.
• Help track CRO spend and study timelines.
• Author and present scientific findings through peer-reviewed publications, conference abstracts, and posters.

Requirements

• PhD in pharmacokinetics, pharmaceutical sciences, or a related discipline.
• A minimum of 3 years of industry experience in DMPK, spanning drug discovery and development, with a track record of contributing to small molecule programs.
• Demonstrated ability to work independently and collaborate effectively within cross-functional project teams.
• Hands-on expertise in in vitro ADME and in vivo PK, with the ability to translate data into actionable drug discovery insights.
• Proficiency in PK data analysis (Phoenix WinNonlin or equivalent) and familiarity with PBPK/PK-PD modeling platforms (Simcyp, GastroPlus, or equivalent).
• Experience contributing to IND-enabling DMPK studies and authoring study reports.
• Working knowledge of FDA, EMA, and ICH guidance relevant to DMPK (DDI, MIST, M9/M10, bioanalytical validation).
• Strong communication and presentation skills, with the ability to clearly convey DMPK science to cross-functional teams.
• Hands-on experience with bioanalytical activities, including LC-MS/MS method development in support of DMPK studies.
• Working knowledge of clinical pharmacology principles, including FIH dose projection, DDI risk assessment, and exposure–response analysis, sufficient to support drug development through early clinical stages.
• Experience working in a startup or early-stage biotech environment (Nice to have).
• Experience contributing to a small molecule program advancing toward or through IND (Nice to have).
• Experience with novel modalities such as TPD, molecular glues, or PROTACs (Nice to have).
• Familiarity with AI/ML-based ADME prediction tools and an interest in integrating computational approaches into the DMPK workflow (Nice to have).

Skills

• Drug Metabolism and Pharmacokinetics (DMPK)
• In Vitro ADME
• Metabolic Stability Assays
• CYP Inhibition/Induction Assays
• Plasma Protein Binding Assays
• Permeability Assays (Caco-2/MDCK)
• Solubility Assays
• Transporter Assays
• In Vitro-In Vivo Correlation (IVIVC)
• Metabolic Soft Spot Analysis
• MetID Analysis
• Bioanalytical Sciences
• LC-MS/MS Method Development
• GLP Compliance
• In Vivo Pharmacokinetics (PK)
• PK Data Analysis (NCA, Compartmental)
• Phoenix WinNonlin
• PK/PD Modeling
• PBPK Modeling
• Simcyp
• GastroPlus
• Allometric Scaling
• Human PK Prediction
• Quantitative Pharmacology
• IND-Enabling Studies
• Regulatory Submissions (IND, CTA)
• ICH Guidance
• Cross-Functional Collaboration
• Clinical Pharmacology
• FIH Dose Projection
• DDI Risk Assessment
• Exposure-Response Analysis
• Induced Proximity Medicines
• Bifunctional Molecules
• TPD
• Molecular Glues
• PROTACs
• AI/ML-based ADME prediction
• Computational Approaches

Location

• San Francisco Bay Area

Work Type

• Full-time
• Onsite

Experience Level

• 3+ years industry experience
• Senior

Education Level

• PhD

Salary/Compensations

• Commensurate with experience

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage
• One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Paid meditation retreats (separate from vacation)
• Reading budget

About the Company

• General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs) using their OmniTAC drug discovery engine.
• They focus on creating molecules that co-opt existing cellular machinery to address previously undruggable therapeutic targets.
• The company is located in the MBC BioLabs at 135 Mississippi Street, an entrepreneurial hub in the Bay Area.
• They foster a 'Work Hard/Play Hard' culture, valuing efficiency and clear communication through well-written documents.
• General Proximity emphasizes a 'writing-first' culture to promote clarity of thought, ideation, and alignment.
• They are committed to growth, seeking independent individuals who can wear multiple hats and providing positive feedback loops for professional development.

Equal Opportunity

• Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed.