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About the Role
We are seeking an experienced and motivated Bioinformatics Scientist to join our Bioinformatics and Data Science Team focused on developing regulated diagnostics products. The ideal candidate will bring deep expertise in NGS technologies with a strong understanding of regulatory environments including CAP/CLIA and IVD product development. The successful candidate will play a crucial role in designing, developing, and optimizing our next generation of genomic assays. This position requires a unique blend of expertise in bioinformatics, extensive experience in assay optimization, analytical validation, strong skills in analytical pipeline development, automation and optimization, a deep understanding of molecular biology, and a passion for transforming complex biological data into actionable insights.
Responsibilities
- Lead bioinformatics design, development and validation efforts in assay development for new and on-market products.
- Coordinate planning, execution, and delivery within timelines and budget constraints as part of project core teams.
- Apply leading edge knowledge in bioinformatics, genomics, and assay technologies to contribute to development of company's concepts and principles and to achieve assay development objectives.
- Drive development study design and all analysis for assay development effort in collaboration with cross-functional teams.
- Develop statistical and machine learning techniques to evaluate assay performance and create optimization strategies.
- Communicate analysis results, methodologies, and scientific findings to internal teams, external collaborators, and stakeholders.
- Develop scalable, production-grade workflows for high-throughput NGS data analysis using AWS and containerized environments.
- Facilitate successful production pipeline deployment by working closely with infrastructure and engineering teams.
- Ensure compliance with regulatory standards (CAP/CLIA, FDA, IVDR) throughout the bioinformatics development lifecycle.
- Contribute to regulatory submissions and audits by providing technical documentation and validation reports.
- Provide scientific guidance and mentorship to junior bioinformatics team members.
Requirements
- PhD or MS in bioinformatics, computational biology, or an adjacent data science field, such as biostatistics, statistics or computer science.
- A minimum of 6 -7 years of experience in bioinformatics analysis, algorithm development, and pipeline implementation.
- Thorough understanding of NGS technologies and various methods for library preparation (WGS, enrichment, RNA-Seq, methylation, etc.).
- Proficiency in quantitative transcriptomics from NGS or expression microarray data in human disease/biology specifically, such as differential expression, dimension reduction, expression-based classifier development, RNA-based signatures, cell type deconvolution.
- Proficiency in machine learning, development of novel bioinformatics methodologies, and algorithms development, including benchmarking of computational methods.
- Proven experience developing and deploying bioinformatics workflows in AWS (e.g., EC2, S3, Step Functions, Batch, Lambda, etc.).
- Strong proficiency in Python, including experience with testing frameworks and SDLC best practices.
- Close collaboration with Quality and Regulatory Affairs team on assay and analysis pipeline development and verification.
- Demonstrated record of technical and scientific leadership, ownership, and independent work.
- Track record of working with wet lab scientists on iterative experiment design, execution, analysis, and interpretation as a tightly integrated team.
- Proficiency in genomics, sequence analysis, and secondary analysis, such as variant calling (e.g., SNVs/MNVs/indels, CNV, structural variants), NGS QC, splicing, circular nucleic acids.
- Strong understanding of germline and somatic mutation processes leading to complex variation and genome-wide biomarkers with potential clinical utility, such as TMB, mutational signatures, LOH.
- Working knowledge of R.
- Experience with relational and non-relational database technologies is a plus.
- Excellent communicator about complex technical topics in an interdisciplinary setting, especially by using data visualizations and diagrams.
- Excellent technical problem solving and troubleshooting skills.
Skills
- Bioinformatics
- NGS technologies
- CAP/CLIA
- IVD product development
- Assay optimization
- Analytical validation
- Analytical pipeline development
- Automation
- Molecular biology
- Genomics
- Statistical techniques
- Machine learning
- AWS
- Containerized environments
- Python
- Testing frameworks
- SDLC best practices
- Quality and Regulatory Affairs
- Genomics
- Sequence analysis
- Variant calling
- NGS QC
- Splicing
- Circular nucleic acids
- Germline and somatic mutation processes
- Genome-wide biomarkers
- TMB
- Mutational signatures
- LOH
- R
- Relational database technologies
- Non-relational database technologies
- Data visualizations
- Diagrams
Location
- San Diego
- South San Francisco
- Remote (US)
Work Type
- Hybrid
- Remote
Experience Level
- 6-7 years of experience
- Senior
Education Level
- PhD
- MS
Salary/Compensations
- $160,000 - $180,000
- $175,000 - $189,000
- $150,000 - $168,000
Benefits
- Competitive compensation
- Competitive benefits
About the Company
- Veracyte is a global diagnostics company whose vision is to transform cancer care for patients all over the world.
- We empower clinicians with the high-value insights they need to guide and assure patients at pivotal moments in the race to diagnose and treat cancer.
- Our Veracyte Diagnostics Platform delivers high-performing cancer tests that are fueled by broad genomic and clinical data, deep bioinformatic and AI capabilities, and a powerful evidence-generation engine, which ultimately drives durable reimbursement and guideline inclusion for our tests, along with new insights to support continued innovation and pipeline development.
- For more information, please visit www.veracyte.com or follow us on LinkedIn or X (Twitter).
- Veracyte is a growing company that offers significant career opportunities if you are curious, driven, patient-oriented and aspire to help us build a great company.
- We are thrilled to be recognized as a 2024 Certified™ Great Place to Work® in both the US and Israel - a testament to our dynamic, inclusive, and inspiring workplace where passion meets purpose.
Equal Opportunity
- Veracyte, Inc. is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status.
- Veracyte participates in E-Verify in the United States.
- View our CCPA Disclosure Notice