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About the Role

Polytope Bio, an Astera project, is developing a post-training engine to connect AI models with high-throughput biology, enabling generative biology applications by aligning AI models with experimental measurements. We seek a Senior/Staff AI Research Scientist to influence modeling, experimental design, and training strategy, working with significant compute and resources to develop and publish new reinforcement learning and generative AI methods.

Responsibilities

Drive core research by developing and executing the scientific vision and cutting-edge modeling approaches.
Design, implement, and improve model post-training methods for biological language models using RL feedback loops.
Architect model training infrastructure and build, run, and debug models, training loops, and evaluation metrics.
Partner with the experimental team to integrate laboratory measurements and model learning into a cohesive system.

Requirements

PhD in machine learning, computational biology, or related field, with 1-2 years post-PhD research/industry experience (or equivalent research accomplishments).
Experience training models from scratch, including debugging training runs.
Hands-on experience with generative diffusion models and/or transformer architectures.
Familiarity with modern reinforcement learning and preference-optimization methods for deep learning.
Demonstrated track record of strong research through publications, open-source work, or shipped models.
Self-directed with a collaborative mindset, comfortable in an early-stage environment.
Comfort operating with ambiguity and a desire to build new initiatives.
Familiarity with biological research (protein modeling, sequence models, structural biology, or adjacent areas) is a plus.
Experience building and scaling training infrastructure on large GPU clusters is a plus.

Skills

Machine Learning
Computational Biology
Generative Diffusion Models
Transformer Architectures
Reinforcement Learning
Preference Optimization
Deep Learning
Model Training
Research
Scientific Vision
Experimental Design
Training Strategy
Infrastructure Architecture
Debugging
Collaboration
Open-Source Development

Location

NYC
SF Bay Area
Remote

Work Type

Full-time
Residency
Potential for Co-founding Role

Experience Level

Senior
Staff
1-2 years post-PhD research or industry experience

Education Level

PhD in machine learning, computational biology, or a related field

Salary/Compensations

$200,000 to $300,000 during the residency

Benefits

Full benefits package including health insurance
Company sponsored retirement plan
Vision
Dental
Authorship of high-impact open-source datasets, methods, and models
Significant secured runway
Dedicated GPU resources

About the Company

Astera is a private foundation dedicated to advancing science and technology for an abundant future.
We support projects that operate like high-velocity startups, focusing on ambitious goals and attracting top talent.
Polytope Bio is a residency project at Astera focused on closing the loop between AI models and high-throughput biology.