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About the Role

This is a hands-on, lab-facing role for a scientist with strong expertise in antibody discovery using in vivo immunization approaches, specifically using single-cell antibody discovery platforms and the 10x Genomics workflow. The successful candidate will play a key role in advancing antibody discovery programs by designing and executing high-throughput discovery strategies, partnering across multidisciplinary teams, and helping deliver high-quality antibody candidates on accelerated timelines.

Responsibilities

Design, execute, and lead antibody discovery campaigns using single B-cell discovery workflows.
Identify and implement opportunities to reduce timelines, improve throughput, and increase operational efficiency.
Represent the antibody discovery group on multidisciplinary project teams and provide scientific leadership on discovery strategy, screening plans, and candidate progression.
Stay current with emerging scientific and technological advances relevant to antibody discovery and single-cell platforms.
Contribute to the external scientific visibility of the Discovery Biologics team through publications, presentations, and scientific engagement.

Requirements

Strong technical expertise with the 10x Genomics Single Cell 5′ V(D)J workflow for antigen-specific antibody isolation, including sample preparation, B-cell sorting, and library generation and/or hands-on experience with single cell antibody platform/s to screen immunized B-cell repertoires, including recovery of antigen-specific antibody sequences.
Strong hands-on laboratory skills in cell culture, molecular biology, high-throughput screening, assay development, and flow cytometry.
Significant hands-on experience in antibody discovery, with specific expertise in in vivo immunization-based discovery approaches using single B-cell screening and sequencing.
Excellent communication, collaboration, and cross-functional partnership skills.
Demonstrated ability to manage multiple projects and competing priorities while maintaining scientific rigor and attention to detail.
Proven success working in a fast-paced, deadline-driven environment.
Highly motivated and collaborative scientist with a strong sense of ownership, urgency, and adaptability.
Established external reputation through publications, presentations, and/or scientific community engagement.
Champion for a varied and inclusive culture.
Experience with next-generation sequencing approaches and related data interpretation in antibody discovery workflows is preferred (including 10x Genomics data).
Experience managing antibody discovery campaigns.

Skills

Antibody Discovery
Antigens
B Cells
Flow Cytometry
High-Throughput Assays
In Vivo Studies
Library Development
Molecular Biology Techniques
Single Cell Analysis

Location

South San Francisco

Work Type

Regular
Domestic/International Relocation
VISA Sponsorship Available
1st - Day Shift

Experience Level

Bachelor's (with 7+ years)
Master's (with 4+ years)
Ph.D.

Education Level

Bachelor's Degree
Master's Degree
Ph.D.

Salary/Compensations

$131,400.00 - $206,800.00

Benefits

Annual bonus and long-term incentive, if applicable.
Medical, dental, vision healthcare and other insurance benefits (for employee and family).
Retirement benefits, including 401(k).
Paid holidays, vacation, and compassionate and sick days.

About the Company

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company.
Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.
We recognize that the diversity in our team is our strength, and we are committed to creating an inclusive environment for all employees.
Successful candidates must demonstrate inclusive behaviours in working with a diverse group of researchers to drive our core mission.
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Equal Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance