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About the Role
Eon is building the infrastructure for large-scale connectomics data collection, reconstruction, and brain simulation. We are seeking a Microscopy Technician to operate and maintain our high-throughput imaging pipeline, capturing high-resolution 3D image volumes of expanded brain tissue.
Responsibilities
- Operate microscopes to acquire high-resolution 3D image volumes of expanded neural tissue, sustaining high throughput and high instrument uptime.
- Help set up, align, and calibrate microscopes and new experiments/equipment as the imaging pipeline scales.
- Handle mounting and storage of expanded hydrogel specimens carefully to protect sample integrity.
- Troubleshoot day-to-day imaging issues and perform routine maintenance on microscopy equipment, escalating more complex instrument problems.
- Implement and maintain imaging pipeline organization, including specimen, throughput, and issue tracking.
Requirements
- BS or MS with 2+ years of hands-on experience operating microscopes, ideally in a core facility, imaging center, or other high-throughput lab.
- Demonstrated, hands-on understanding of the theory and practice of modern fluorescence microscopy and associated instrumentation.
- Comfortable with day-to-day microscope alignment, calibration, and basic troubleshooting.
- Strong organizational skills and the ability to keep a multi-step pipeline running smoothly with minimal oversight.
- Familiarity with image acquisition and analysis software (e.g., Fiji, Imaris, or similar).
- Ability to work collaboratively in a dynamic, fast-paced research environment.
- Experience with expansion microscopy.
- Hands-on familiarity with spinning-disk confocal or light-sheet systems.
- Comfort working with custom or home-built optical setups (assembling optics, aligning lasers, and managing software issues).
- Basic scripting for acquisition or image processing.
Skills
- Microscopy operation
- High-throughput imaging
- Image acquisition
- Instrument troubleshooting
- Routine maintenance
- Pipeline organization
- Fluorescence microscopy
- Microscope alignment
- Calibration
- Image acquisition software
- Image analysis software
- Expansion microscopy
- Spinning-disk confocal
- Light-sheet systems
- Custom optical setups
- Scripting
Location
- Bay Area
Work Type
- On-site
Experience Level
- 2+ years of hands-on experience
Education Level
- BS or MS
Salary/Compensations
- $90,000–$125,000
Benefits
- Equity
- Benefits
About the Company
- Eon is building the infrastructure for large-scale connectomics data collection, reconstruction, and brain simulation.
- Our mission is to enable the safe and scalable development of brain emulation technology, beginning with digital twins of model organisms.
- We are developing an end-to-end platform that spans tissue preparation, high-throughput microscopy, large-scale image processing, neural reconstruction, connectome-based modeling, and embodied simulation.
- We are looking for exceptional engineers and scientists who can help turn biological brain data into usable computational systems.