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About the Role

As a Scientist II on Xaira's Genomics Core team, you will be responsible for generating high-quality sequencing data to support the company's AI-driven drug discovery platform. This hands-on laboratory role involves designing, developing, and executing next-generation sequencing (NGS) workflows, primarily using Illumina platforms, and collaborating with cross-functional teams to advance research.

Responsibilities

• Perform high-quality next-generation sequencing operations across Illumina platforms.
• Independently design, develop, optimize, validate, and troubleshoot sequencing workflows.
• Prepare and QC sequencing libraries for various applications including 10x Genomics single-cell RNA sequencing, bulk RNA sequencing, CRISPR-based sequencing assays, and targeted sequencing workflows.
• Design sequencing strategies and provide technical guidance to cross-functional project teams.
• Partner with Functional Genomics scientists to support Perturb-seq, pooled CRISPR screening, and guide sequencing.
• Collaborate with Automation Engineers to develop, implement, and scale automated library preparation and sequencing workflows.
• Work closely with Computational Biology teams to ensure sequencing data meets quality standards for downstream analysis and AI/ML applications.
• Serve as a technical subject matter expert for sequencing technologies by evaluating new methodologies and troubleshooting complex technical challenges.
• Perform routine maintenance, calibration, and troubleshooting of sequencing instrumentation and associated laboratory equipment.
• Manage sequencing sample intake, experimental tracking, reagent inventory, and laboratory documentation.
• Maintain accurate experimental records using electronic laboratory notebooks (ELN) and laboratory information management systems (LIMS).
• Evaluate and implement emerging sequencing technologies, library preparation methods, and genomics workflows.
• Present technical updates, experimental findings, and workflow improvements to cross-functional project teams.
• Contribute to laboratory operations while ensuring compliance with safety and quality standards.

Requirements

• Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline with 2+ years of industry experience, or M.S./B.S. with equivalent industry experience.
• Extensive hands-on experience operating Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq.
• Extensive hands-on experience with 10x Genomics workflows: 3’, 5’, ATAC, Multiome, Flex, etc.
• Strong expertise in next-generation sequencing library preparation, including single-cell RNA-seq, bulk RNA-seq, CRISPR-based sequencing assays, and targeted sequencing workflows.
• Demonstrated experience supporting CRISPR-based genomics workflows, including Perturb-seq, pooled CRISPR screens, guide sequencing, or related functional genomics applications.
• Demonstrated ability to independently design, optimize, troubleshoot, and execute complex genomics experiments with minimal supervision.
• Proven experience developing, validating, and implementing new NGS workflows while driving improvements in data quality, throughput, and reproducibility.
• Strong understanding of sequencing quality control methods, library characterization techniques, and experimental troubleshooting.
• Experience collaborating with multidisciplinary teams, including molecular biologists, automation engineers, and computational scientists.
• Ability to independently prioritize multiple projects while providing scientific and technical leadership within cross-functional teams.
• Excellent written and verbal communication skills, including the ability to present technical findings to diverse scientific audiences.
• A proactive, collaborative mindset with strong troubleshooting and problem-solving abilities.
• Enthusiasm for working in a highly interdisciplinary startup environment.
• Experience working in a genomics core facility or high-throughput sequencing laboratory.
• Experience developing or supporting automated library preparation workflows.
• Experience with additional 10x Genomics applications such as ATAC, Immune Profiling, Multiome, etc.
• Experience with molecular cloning, cell engineering, lentiviral workflows, or other functional genomics techniques.
• Basic familiarity with bioinformatics tools, NGS data quality assessment, and sequencing data analysis pipelines.
• Experience evaluating and implementing emerging sequencing technologies.
• Experience supporting AI/ML-driven biological research through generation of high-quality genomic datasets.

Skills

• Next-generation sequencing (NGS)
• Illumina sequencing platforms (MiSeq, NextSeq, NovaSeq)
• 10x Genomics workflows
• Single-cell RNA sequencing
• Bulk RNA sequencing
• CRISPR-based sequencing assays
• Targeted sequencing workflows
• Perturb-seq
• Pooled CRISPR screening
• Guide sequencing
• Library preparation
• Quality control (QC)
• Experimental design
• Troubleshooting
• Automation
• Bioinformatics tools
• NGS data quality assessment
• Sequencing data analysis pipelines
• Molecular cloning
• Cell engineering
• Lentiviral workflows
• Functional genomics techniques

Location

• San Francisco Bay Area
• Seattle
• London

Work Type

• Onsite

Experience Level

• Scientist II
• 2+ years of industry experience (with Ph.D.)
• Equivalent industry experience (with M.S./B.S.)

Education Level

• Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline
• M.S./B.S.

Salary/Compensations

• $124,000 to $155,000 annually

Benefits

• Competitive compensation and benefits package
• Open, flexible, and friendly work environment
• Platform to develop long-term careers
• Base salary
• Bonus
• Equity

About the Company

• Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
• The company is leading the development of generative AI models to design protein and antibody therapeutics.
• It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
• These technologies aim to continually enable the identification of novel therapies and to improve success in drug development.

Equal Opportunity

• Xaira Therapeutics an equal-opportunity employer.
• We believe that our strength is in our differences.
• Our goal to build a diverse and inclusive team began on day one, and it will never end.