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About the Role

Seeking a Scientist II to join the Nucleic Acid Design and Discovery (NADD) team, focusing on oligonucleotide therapeutics discovery and supporting RNAi-based research through synthesis, characterization, and collaboration.

Responsibilities

• Design and execute oligonucleotide synthesis and purification workflows.
• Perform HPLC and mass spectrometry analysis for characterization and impurity profiling.
• Support RNAi and nucleic acid therapeutic discovery across neuroscience, immunology, and oncology programs.
• Develop and scale up synthesis of lead oligonucleotide candidates for preclinical studies.
• Collaborate with cross-functional teams to integrate chemistry and biology data.
• Maintain and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
• Conduct literature reviews and contribute to experimental design and strategy.

Requirements

• BS/MS in Organic Chemistry or related field.
• Hands-on experience with oligonucleotide synthesis, purification, and characterization.
• Experience with automated oligo synthesizers, HPLC, and mass spectrometry.
• Understanding of RNAi, nucleic acid therapeutics, and modification chemistries preferred.
• Industry experience in biotech/pharma R&D is a plus.

Location

• South San Francisco, CA

Work Type

• Long Term Contract

Experience Level

• Scientist II

Education Level

• BS/MS in Organic Chemistry or related field

Salary/Compensations

• $53/hr on W2

Benefits

• Medical
• Dental
• Vision
• Paid Sick leave
• 401K

About the Company

• Our client is a world leader in biotechnology and gene therapy.