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About the Role

Join our Bioanalytical Sciences team to develop and execute bioanalytical assays for preclinical translation and development. This hands-on role involves evaluating PRINT™-delivered payloads in disease-relevant contexts to generate data guiding candidate selection and advancing therapeutic programs toward clinical development, focusing on obesity and metabolic disease programs.

Responsibilities

• Design, develop, validate, and execute in vitro, cell-based, and ex vivo assays to evaluate the efficacy, pharmacology, and delivery of various payloads using PRINT™ technology.
• Develop and execute pharmacodynamic assays to measure transgene expression, protein production and secretion, enzymatic activity, receptor engagement, and downstream biological responses.
• Develop and run cell-based functional assays to evaluate therapeutic efficacy across obesity and other metabolic diseases.
• Establish assays using primary cells, immortalized cell lines, and tissue-derived samples to support translational studies.
• Collaborate with in vivo pharmacology teams to analyze plasma and tissue samples from rodent and non-human primate studies.
• Ensure accurate and reliable results through meticulous hands-on execution and record-keeping.
• Support PK/PD characterization by generating quantitative bioanalytical data to inform dose selection and mechanism of action.
• Contribute to assay transfer, qualification, documentation, and implementation of best laboratory practices.
• Collaborate with internal teams and partners to integrate and optimize current and new assay technologies and methodologies.
• Analyze experimental data, interpret results, and present findings in team meetings.
• Contribute to troubleshooting and refining assay protocols.
• Stay up to date with relevant scientific literature and emerging technologies.
• Provide input on potential improvements or innovations in assay development and genomic medicine applications.
• Contribute to data packages supporting IND-enabling studies, partnership diligence, and investor milestones.

Requirements

• Ph.D. in molecular biology, biochemistry, pharmacology, cell biology, or a closely related field (relevant industry experience considered in lieu of Ph.D.).
• Proficiency across standard molecular/biochemical assay platforms: ELISA, MSD, AlphaLISA, ddPCR, qPCR, Western blot, flow cytometry, and microscopy.
• Experience in mammalian cell culture to support cell-based assays.
• Ability to independently design experiments, troubleshoot, and interpret data.
• Clear and organized scientific communicator, comfortable presenting data to cross-functional audiences.
• Familiarity with obesity biology, metabolic disease, GPCR pharmacology.
• Experience with genomic medicines, mRNA, or RNA-based therapeutic modalities.
• Exposure to NHP or translational PK/PD study design.
• Experience with animal models of disease is a plus.
• Familiarity with HTS or automated liquid handling platforms.

Skills

• ELISA
• MSD
• AlphaLISA
• ddPCR
• qPCR
• Western blot
• Flow cytometry
• Microscopy
• Mammalian cell culture
• Obesity biology
• Metabolic disease
• GPCR pharmacology
• Genomic medicines
• mRNA
• RNA-based therapeutic modalities
• NHP PK/PD study design
• Translational PK/PD study design
• Animal models of disease
• HTS
• Automated liquid handling platforms

Location

• South San Francisco

Work Type

• Full-time

Experience Level

• Scientist / Senior Scientist

Education Level

• Ph.D.

Benefits

• Competitive salary
• Equity
• Benefits

About the Company

• Addition Therapeutics is at the forefront of biotechnology innovation, building the next generation of gene therapy using our proprietary PRINT™ (Programmable RNA-guided Integration Technology) platform.
• PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome.
• We are a Series A-stage company with programs across rare and common diseases.

Equal Opportunity

• Addition Therapeutics is an equal opportunity employer.
• We value diverse perspectives and are committed to building an inclusive team.