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About the Role

Serve as a strategic finance partner to the R&D organization, supporting critical investment decisions across the development portfolio by delivering financial insights, forecasting, and decision support. Translate scientific and clinical strategies into actionable financial plans, ensuring effective resource deployment across programs.

Responsibilities

• Partner with R&D leadership and project teams to develop portfolio and program-level financial plans
• Lead scenario modeling, cost-benefit analyses, and vendor investment decisions
• Support clinical program investment decisions and other high-priority strategic initiatives
• Deliver accurate and timely forecasts, budgets, and long-range plans for R&D functions
• Prepare and present financial analyses to senior leadership, including materials for Board meetings
• Provide variance analysis and actionable insights to inform decision-making
• Partner closely with Accounting to align budget vs actuals, including accruals, coding, and variance reporting
• Collaborate with functional stakeholders to translate scientific and operational plans into financial outcomes
• Drive improvements in FP&A processes, reporting, and forecasting accuracy
• Partner with the Head of FP&A to enhance and automate allocation methodologies across programs and indications
• Build communication channels across Maze for sharing information
• Influence Senior Management decisions through persuasive arguments
• Respectfully address differing opinions leading to support of decisions
• Champion partnerships and connections across Maze
• Proactively address issues that could result in breakdown of team relationships
• Spotlight team and individual contributions in public forums
• Address gaps and leverage strengths to get best results
• Maintain a steadying presence and clarify priorities during change
• Anticipate and remove barriers that put functional/corporate goals at risk
• Remove barriers to staff development and empower them to make their own decisions
• Stay current on industry trends and keep direct-reports prepared and responsive

Requirements

• Bachelor’s degree in Finance, Accounting, Economics, or related field; MBA or equivalent experience preferred
• 10+ years of experience in the pharmaceutical or biotech industry, including significant FP&A experience
• Experience supporting R&D or development organizations strongly preferred
• Clinical trial forecasting and accruals experience preferred
• Advanced proficiency in Excel and PowerPoint
• Experience with financial systems such as NetSuite, Coupa, and Anaplan, or similar tools
• Strong financial modeling and forecasting capabilities, including ad hoc analysis
• Proven ability to build strong relationships and influence cross-functional stakeholders
• Ability to translate complex scientific and strategic concepts into clear financial insights
• Excellent written and verbal communication
• Highly organized with the ability to manage multiple priorities and meet deadlines
• Detail-oriented and solution-driven, with a focus on continuous improvement
• Collaborative mindset with a focus on improving efficiency and effectiveness
• Interest in exploring applications of AI to enhance FP&A processes

Skills

• Financial Planning & Analysis (FP&A)
• Scenario modeling
• Cost-benefit analyses
• Financial forecasting
• Budgeting
• Long-range planning
• Variance analysis
• Financial reporting
• Financial modeling
• Excel
• PowerPoint
• NetSuite
• Coupa
• Anaplan
• Communication
• Influence
• Teamwork
• Collaboration
• Execution
• Problem-solving
• AI applications in FP&A

Location

• South San Francisco headquarters

Work Type

• Hybrid
• Full-time

Experience Level

• Director
• 10+ years of experience

Education Level

• Bachelor's degree in Finance, Accounting, Economics, or related field
• MBA or equivalent experience preferred

Salary/Compensations

• $227,000 to $277,000
• Eligible for an annual performance bonus

Benefits

• Competitive medical, dental, and vision insurance
• Mental health offerings
• Equity incentive plan
• 401(k) program with employer match
• Generous holiday and PTO policy

About the Company

• Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases.
• Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease.
• We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.
• Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases.
• We are fostering a culture that encourages vision, initiative and the development of talent.
• Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work.
• While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
• Our Core Values: Further Together, Impact Obsessed, Stand True.