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About the Role

The Senior Scientist will join the Respiratory Biology Discovery group to contribute to target identification, validation, and mechanism-of-action studies for early discovery programs in chronic lung diseases. The role involves leveraging advanced human-relevant models to generate data informing target prioritization and therapeutic strategy.

Responsibilities

• Design experimental strategies to interrogate epithelial, stromal, vascular, and immune-cell interactions driving chronic lung disease pathogenesis.
• Develop and apply disease-relevant experimental systems, including primary airway epithelial cultures, air-liquid interface (ALI) models, organoid systems, precision-cut lung slices (PCLS), and co-culture platforms.
• Generate mechanistic datasets to investigate epithelial dysfunction, tissue remodeling, fibrosis, immune responses, and regenerative biology in chronic lung diseases.
• Utilize imaging, transcriptomic, proteomic, and spatial profiling approaches to support target validation and translational hypothesis generation.
• Support translational biomarker discovery and validation using patient-derived samples and multiplex biomarker platforms (Luminex, Olink, AlphaLISA).
• Partner with computational biology and translational teams to integrate multi-omics datasets and identify disease-relevant pathways and biomarkers.
• Support evaluation of biologics, small molecules, and emerging therapeutic modalities using human disease-relevant model systems.
• Synthesize and interpret complex biological datasets to support target prioritization, mechanism-of-action studies, and portfolio decision-making.
• Collaborate across biology, pharmacology, DMPK, and translational and clinical teams within a matrixed discovery environment.

Requirements

• Ph.D. in Biology, Immunology, Pulmonary Biology, Bioengineering, Pharmacology, Cell Biology, Regenerative Medicine or related discipline and relevant experience.
• Demonstrated expertise in respiratory biology and human primary cell-based systems, including airway and/or alveolar epithelial models.
• Strong experience with ALI cultures, organoids, co-culture systems, tissue-engineered models, organ-on-chip platforms, and/or precision-cut lung slices.
• Experience in target validation and translational biology within respiratory, immunology, fibrosis, regeneration, or related therapeutic areas.
• Expertise with imaging-based approaches including IHC, IF, ICC, confocal microscopy, high-content imaging, image analysis, and quantitative phenotyping.
• Ability to independently design, execute, troubleshoot, and interpret complex experimental studies.
• Strong scientific communication skills and ability to present findings in cross-functional settings.
• Prior experience in respiratory drug discovery, fibrosis, tissue remodeling, regenerative biology, or inflammatory lung disease research.
• Experience with macrophage, fibroblast, epithelial, or immune-stromal co-culture systems.
• Experience working with patient-derived respiratory tissues and primary human lung cells.
• Familiarity with transcriptomic datasets including bulk RNA-seq and single-cell RNA-seq.
• Experience with organoid biology, human tissue-based models, or spatial biology approaches.
• Knowledge of translational biomarker strategies and human disease-relevant endpoints.
• San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
• Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.

Skills

• Cell Culture Techniques
• Image Analysis
• Immunocytochemistry (ICC)
• Immunohistochemistry (IHC)
• Organoid Culture
• Pulmonary Disease Research
• Pulmonary Disorders
• Pulmonary Fibrosis Treatment
• Target Validation
• Human primary cell-based systems
• ALI cultures
• Organoids
• Co-culture systems
• Tissue-engineered models
• Organ-on-chip platforms
• Precision-cut lung slices
• Imaging-based approaches
• Confocal microscopy
• High-content imaging
• Quantitative phenotyping
• Transcriptomic datasets
• Bulk RNA-seq
• Single-cell RNA-seq
• Spatial biology approaches
• Translational biomarker strategies
• Macrophage co-culture systems
• Fibroblast co-culture systems
• Epithelial co-culture systems
• Immune-stromal co-culture systems
• Patient-derived respiratory tissues
• Primary human lung cells
• Luminex
• Olink
• AlphaLISA

Location

• Domestic/International

Work Type

• Regular
• 10% Travel

Experience Level

• Senior Scientist
• Ph.D. level

Education Level

• Ph.D.

Salary/Compensations

• $131,400.00 - $206,800.00

Benefits

• Eligible for annual bonus and long-term incentive, if applicable.
• Comprehensive package of benefits.
• Medical, dental, vision healthcare and other insurance benefits (for employee and family).
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

About the Company

• Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities.
• We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
• The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
• We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Equal Opportunity

• As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
• As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
• For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights
• EEOC GINA Supplement
• Learn more about your rights, including under California, Colorado and other US State Acts