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About the Role

This role focuses on performing molecular biology and biochemistry experiments at the benchtop for the development of engineered enzymes critical to our core technology. You will ensure a continuous supply of high-quality protein material and develop/optimize next-generation enzymatic assay protocols in a highly interdisciplinary environment.

Responsibilities

• Prepare, purify, and provide protein materials for daily experimental workflows.
• Perform bacterial protein expression and purification using gravity columns and FPLC chromatography.
• Conduct protein characterization methods including SDS-PAGE analysis, UV/Vis quantification, and BCA quantification.
• Perform routine molecular biology techniques, including bacterial transformation, plasmid purification, and basic E. coli culture.
• Develop and optimize novel assays for protein conjugation and enzymatic activity measurement.
• Execute high-throughput protein production and activity screening, including design and construction of DNA libraries.
• Process, analyze, and troubleshoot experimental data and technical issues.
• Maintain detailed records of all experimental work and analysis.
• Communicate experimental results, data analysis, and next steps to team members and leadership.
• Contribute individually and collaborate with synthesis, surface chemistry, engineering, sequencing, and bioinformatics teams.

Requirements

• Bachelor's degree in Chemistry, Biochemistry, Molecular Biology, or a closely related field.
• Hands-on experience developing, optimizing, and executing biochemistry and molecular biology protocols in a research laboratory environment.
• Must be a creative and detail-oriented person with excellent analytical, verbal, and written communication skills.
• Exceptional collaboration skills and ability to work seamlessly in a dynamic and fast-paced environment.
• Must be able to move about the laboratory and office environment regularly, including standing and walking for extended periods (up to 6–8 hours per day).
• Must have fine motor skills and steady hands for handling instruments, operating equipment, pipetting accurately, and performing repetitive benchwork with precision.
• Must be able to lift and carry up to 40 pounds occasionally.
• Must have sufficient visual acuity for reading small print, instrument displays, and computer monitors, including close vision, color vision, and the ability to adjust focus.
• Must be able to wear appropriate personal protective equipment (PPE) such as lab coats, gloves, and safety goggles as required.

Skills

• Molecular biology
• Biochemistry
• Bacterial protein expression
• Protein purification
• Gravity columns
• FPLC chromatography
• SDS-PAGE analysis
• UV/Vis quantification
• BCA quantification
• Bacterial transformation
• Plasmid purification
• E. coli culture
• Assay development
• Assay optimization
• Protein conjugation
• Enzymatic activity measurement
• High-throughput protein production
• Activity screening
• DNA library design
• DNA library construction
• Data analysis
• Troubleshooting
• Record keeping
• Communication
• Collaboration
• Bioconjugation
• Protein attachment to solid surfaces
• Liquid handling laboratory automation
• Next Generation DNA sequencing (NGS) methods

Location

• South San Francisco

Work Type

• Onsite
• Laboratory

Experience Level

• Master's degree or prior relevant industry experience is a plus
• Experience in a biotech or pharma R&D environment is highly desirable

Education Level

• Bachelor's degree in Chemistry, Biochemistry, Molecular Biology, or a closely related field.