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About the Role
ORIC Pharmaceuticals is seeking a lab-based, highly motivated Senior Scientist in Analytical Sciences to provide analytical leadership on cross-functional teams and contribute to bringing new therapeutics to cancer patients. The role involves reporting to the Sr. Director of Analytical Sciences.
Responsibilities
- Lead analytical development and product characterization activities for drug development portfolios.
- Provide oversight, technical guidance, and tactical direction for analytical method development, transfer, validation, release, and stability testing at CDMOs.
- Function as a subject matter expert for physical/chemical characterization of NCEs at CROs.
- Conceptualize, design, and conduct experiments; interpret and present data and conclusions to various audiences, including senior leadership.
- Solve challenging problems using analytical techniques.
- Maintain timely and accurate lab records consistent with good documentation practices.
- Work in compliance with all applicable laboratory, safety, quality, and regulatory guidance and requirements.
- Create and execute strategic plans for projects, ensuring product requirements are met.
- Provide technical guidance during investigations at CDMOs/CROs in collaboration with quality.
- Author and review technical reports, technical data packages, and relevant sections in health authority filings.
- Support due diligence/partnership efforts.
- Manage project budgets, oversee progress, and coordinate contracts, POs, and invoices.
- Ensure high-quality deliverables are met in a timely manner.
Requirements
- Ph.D. in analytical chemistry or related field with 3+ years of experience in drug discovery and development.
- Demonstrated problem-solving skills, critical thinking, and adaptability.
- Ability to take initiative, ownership, and provide strategic input.
- Proven record of sustained laboratory achievement and innovation.
- Extensive hands-on experience in analytical technologies including UHPLC, GC, LC-MS, GC-MS, SFC, dissolution, disintegration, wet chemistry, DSC, TGA, PSD, XRPD, spectroscopic and compendial methods.
- Thorough mechanistic understanding of analytical technologies and development for new drug candidates.
- Awareness and knowledge of cross-functional activities such as DMPK, toxicology, and clinical development.
- Ability to work independently and efficiently in a collaborative, fast-paced, integrated, multidisciplinary team environment.
- Experience in writing and reviewing product specifications, method validation protocols/reports, analytical methods, and development reports.
- Working understanding of ICH and regulatory guidance.
- Strong attention to detail.
- Prior experience working in lab, GLP, and cGMP environments.
- Scientific excellence demonstrated by publications, presentations, and leadership/engagement in scientific/professional communities.
Skills
- Analytical development
- Product characterization
- Analytical method development
- Method transfer
- Method validation
- Release testing
- Stability testing
- Physical/chemical characterization
- Experiment design
- Data interpretation
- Problem-solving
- Project management
- Budget planning
- UHPLC
- GC
- LC-MS
- GC-MS
- SFC
- Dissolution
- Disintegration
- Wet chemistry
- DSC
- TGA
- PSD
- XRPD
- Spectroscopic methods
- Compendial methods
- ICH guidelines
- Regulatory guidance
Location
- South San Francisco, California
Work Type
- Lab-based
- On-site
Experience Level
- Senior Scientist
- 3+ years of experience
Education Level
- Ph.D. in analytical chemistry or related field
Salary/Compensations
- $150,000-$180,000
About the Company
- ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer.
- ORIC’s clinical stage product candidates include (1) rinzimetostat (ORIC-944), an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers.
- ORIC® is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms.
- ORIC has offices in South San Francisco and San Diego, California.
Equal Opportunity
- ORIC Pharmaceuticals, Inc. is an equal opportunity employer.
- ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristics.