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About the Role

Performs complex bioanalytical method development using LC-MS/MS, with a focus on small molecules and biologics in various biological matrices.

Responsibilities

• Performs complex bioanalytical method development and revision tasks on LC-MS/MS Instruments.
• Develops methods for small molecules in animal and human biological matrices using various extraction techniques.
• Develops methods for biologics using LCMS/MS, including large molecules, ADCs, bispecific compounds, small peptides, and ceramides.
• Adjusts chromatographic and MS conditions to improve sensitivity, selectivity, peak shape, and robustness.
• Serves as a Subject Matter Expert (SME) for bioanalytical analysis of small molecules via LCMSMS.
• Evaluates and minimizes matrix effects, carryover, interferences, and variability.
• Establishes and manages internal standards and assesses potential co-medication/endogenous interferences.
• Plans and supports method validation (accuracy, precision, linearity, selectivity, stability, dilution integrity, etc.).
• Documents method development, optimization, and validation work clearly in protocols and reports.
• Provides technical oversight during routine sample analysis using developed/validated methods.
• Reviews chromatograms and data integration, investigates atypical results, and recommends corrective actions.
• Provides technical oversight to R&D chemists performing method development.
• Provides technical training to new chemists and when corrective/preventative actions are required.
• Coordinates, organizes, and integrates resources for large complex projects, adapting to changing priorities.
• Generates analytical test results in compliance with SOPs, protocols, study plans, and GLP requirements.
• Documents and communicates deviations to the Principal Investigator or Study Director.
• Generates method procedures, results, validation, re-validation, and analytical reports for regulatory submission.
• Records raw data promptly and accurately in compliance with OECD Principles of Good Laboratory Practice.
• Works in a safe manner, complying with all relevant safety procedures.
• Exercises health precautions to minimize risk and ensure study integrity, communicating relevant health conditions to management.

Requirements

• MSc or Ph.D. in Analytical chemistry or a related field with a minimum of 5 years of related experience directly involved in the advanced-level use and applications of LC-MS/MS.
• BSc. /College Diploma in Analytical Chemistry or a related field with a minimum of 10 years of related experience directly involved in the advanced-level use and applications of LC-MS/MS.

Skills

• LC-MS/MS
• Bioanalytical method development
• Small molecule analysis
• Biologics analysis
• Chromatography
• Mass Spectrometry
• Method validation
• Data analysis
• GLP
• SOPs
• Protocol development
• Report writing

Location

• Onsite (North York)

Work Type

• Full Time
• Onsite

Experience Level

• Minimum 5 years of related experience (with MSc/PhD)
• Minimum 10 years of related experience (with BSc/College Diploma)

Education Level

• MSc or PhD in Analytical Chemistry or related field
• BSc or College Diploma in Analytical Chemistry or related field

Salary/Compensations

• $80,000-$110,000

About the Company

• BioPharma Services Inc.