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About the Role

Structure Therapeutics is seeking a Head of Data (Senior Director or Executive Director) to lead the development and governance of its Knowledge System, the core technical asset powering the company's AI initiatives. This strategic role involves building and managing a domain-specific data layer, including ontologies, semantic enrichments, and digital twins, to enhance AI capabilities and drive differentiated value in drug discovery.

Responsibilities

Build and maintain the enriched data layer that powers all AI at Structure.
Define and maintain ontologies and semantic enrichments.
Build and manage the data catalog.
Curate datasets from Clinical, Manufacturing, R&D, and G&A for AI model training and inference.
Own the digital twins for manufacturing processes, clinical operations, and supply chain.
Lead a team of data engineers building and maintaining data pipelines for AI.
Own data quality, documentation, and governance across AI data assets.
Manage data stewards accountable for quality in specific domains.
Operationalize FAIR data principles across AI data assets.
Ensure the Knowledge System meets data governance requirements, including GxP, IP protection, and data use agreements.
Build and manage data environments for vendor evaluation.
Align the data roadmap with the needs of Clinical, G&A, CMC, Commercial, and R&D business units.

Requirements

12+ years of experience in data engineering, data architecture, or knowledge management.
Meaningful experience in a regulated data-intensive industry (biotech, pharma, health tech, or equivalent).
Demonstrated track record of building knowledge infrastructure in complex domains.
Fluency in modern data stack: cloud data warehouses and lake house architectures (Snowflake, Databricks, Iceberg), orchestration, and streaming ingestion (Kafka).
Experience with ontologies, knowledge graphs, or semantic data modeling.
Working knowledge of GxP data governance frameworks (GCP, GMP, 21 CFR Part 11).
Strong FAIR principles fluency and operational experience.
Experience leading data engineers and data stewards.
Collaborative approach, working effectively with AI engineering, product management, business units, and IT.
Familiarity with biopharma data systems (EDC, CTMS, LIMS, MES, ERP).
Familiarity with how data feeds AI/ML pipelines and MLOps data requirements.
Deep biopharma domain expertise (for Executive Director level).
Exceptional people development skills (for Executive Director level).
Executive presence and ability to communicate at the executive level (for Executive Director level).
External thought leadership in the biopharma data and knowledge management community (for Executive Director level).

Skills

Data Engineering
Data Architecture
Knowledge Management
Ontologies
Semantic Data Modeling
Knowledge Graphs
Data Cataloging
Data Curation
Digital Twins
Data Pipelines
Data Quality
Data Governance
FAIR Principles
GxP Data Governance
Cloud Data Warehouses
Lake House Architectures
Snowflake
Databricks
Iceberg
Orchestration
Streaming Ingestion
Kafka
Biopharma Data Systems (EDC, CTMS, LIMS, MES, ERP)
AI/ML Data Requirements
MLOps

Location

California
Shanghai

Work Type

Full-time
Onsite

Experience Level

Senior Director
Executive Director
12+ years of experience

Education Level

BS degree required
MS or PhD preferred
BS/MS/PhD in Computer Science, Data Science, Bioinformatics, Life Sciences, or a related field

Salary/Compensations

$265,000-$356,000

Benefits

Annual performance incentive bonus
New hire equity
Ongoing performance-based equity
Medical insurance
Dental insurance
Vision insurance
401k match
Unlimited PTO
Paid holidays
Winter shutdown

About the Company

Structure Therapeutics develops life-changing medicines using advanced structure-based and computational drug discovery technology.
The company's platform combines advancements in molecular interaction visualization, computational chemistry, and data integration to design orally available small molecule medicines.
Structure Therapeutics is advancing a clinical-stage pipeline focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.
The company is led by experienced international drug innovators and financed by top-tier global life sciences investors.
Structure Therapeutics completed an IPO in February 2023.
The company has offices in California and Shanghai, benefiting from life science innovation hubs in both the US and China.

Equal Opportunity

Structure Therapeutics Inc. is an Equal-Opportunity Employer.