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About the Role

We are looking for a motivated Scientist with expertise in RNA analytical development and quality control. This role focuses on developing, optimizing, and validating analytical methods while supporting QC testing of RNA drug substances and final formulations, offering strong growth opportunities in a fast-paced, cross-functional environment.

Responsibilities

• Independently develop, optimize, and validate analytical methods for characterizing and quantifying plasmids, IVT impurities, RNA drug substances, lipids, and small molecules.
• Utilize techniques including CGE, LC-UV/MS, LC-CAD, qPCR, and ELISA.
• Troubleshoot analytical methods and instrumentation issues.
• Conduct and interpret QC testing to support Process Development and Formulation teams by assessing materials for in vitro and in vivo studies.
• Analyze and interpret experimental data; effectively communicate findings to cross-functional teams.
• Contribute to troubleshooting and continuous improvement of analytical methods and workflows.
• Maintain accurate and detailed laboratory records.
• Author and review SOPs, analytical methods, and qualification/validation reports to facilitate QC transfer.
• Collaborate with Discovery, Process Development, and formulation teams to support research and development efforts.

Requirements

• Proven experience in developing and validating quantitative analytical methods for RNA and small molecules.
• Strong analytical thinking and problem-solving skills.
• Excellent communication and technical writing abilities.
• Ability to excel in a fast-paced startup environment.
• Self-motivated, adaptable, and eager to learn.

Skills

• CGE
• LC-UV/MS
• LC-CAD
• qPCR
• ELISA
• Nanopore
• HPLC (CAD/UV)
• Mass Spectrometry

Location

• South San Francisco, CA

Work Type

• Full-time

Experience Level

• 1-3 years of industry experience (Ph.D.)
• 6-8 years of industry experience (Master's)
• 9-10 years of industry experience (Bachelor's)

Education Level

• Ph.D. in Analytical Chemistry, Biochemistry, or related field
• Master's
• Bachelor's

Salary/Compensations

• $111,000-$140,000

About the Company

• Addition Therapeutics leads in biotechnology innovation, advancing transformative therapies through our proprietary PRINT™ platform (Precise RNA-mediated Insertion of Transgenes). PRINT™ redefines genetic medicine by enabling RNA-only therapeutics that insert genetic elements into safe harbor sites within the genome. From our advanced labs in South San Francisco, we drive scientific breakthroughs and foster a collaborative, mission-driven culture dedicated to improving patient lives.

Equal Opportunity

• We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.