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About the Role
The Molecular Profiling Senior Scientist will work primarily with our research division's Discovery Oncology organization, providing targeted and NGS gene expression profiling support to reverse translation and preclinical target and biomarker validation efforts. Early discovery and pre-clinical work in support of other therapeutic areas will also be provided as needed. This high throughput lab requires an organized, highly motivated individual who can work collaboratively across multiple organizations in the development of therapeutic targets in the Discovery Portfolio.
Responsibilities
- Provide insight and guidance to cross-functional collaborators regarding experimental design for gene expression-based work
- Wet-lab support for project-based work including RNA isolation and gene expression profiling from bulk tissue, bulk sorted cell, and single cell populations
- Present and lead discussions on experimental results and data interpretation at team and/or department meetings
- Serve as Molecular Profiling representative to the Oncology translational research group as well as other program teams
Requirements
- Experience with molecular biology techniques, including RNA/DNA isolation and NGS library preparation
- Experience with targeted RT-qPCR and NGS platforms
- Experience with multi-omics NGS platforms, low cell number sorted populations, and/or single-cell RNAseq
- Experience in analysis of mid-density and/or whole transcriptomics gene expression data types
- Prior experience in Oncology or Immunology
- Strong interpersonal skills with an ability to contribute effectively in a team-based environment
- Highly organized and able to manage time effectively
- Ability to interface with translational, discovery, and clinical cross-functional colleagues to drive assay development and implementation into discovery and/or clinical programs as needed
Skills
- DNA Isolation
- Immunology
- Molecular Biology
- Next Generation Sequencing (NGS)
- Oncology
- RNA Isolation
- RNA Sequencing
- RNA/DNA QC platforms such as the Qubit, Fragment Analyzer, Agilent Bioanalyzer or Tapestation
- Liquid automation for sample RNA/DNA isolation and NGS library prep
- NGS analysis data visualization software such as Cell Ranger, Partek, OmniBrowser, or BioTuring
- Illumina BaseSpace
- Illumina Dragen
- Spotfire
- Graphpad Prism
- Ingenuity Pathway Analysis
Location
- Domestic
Work Type
- Regular
Experience Level
- 7+ years (Bachelor's)
- 4+ years (Master's)
- Ph.D.
Education Level
- Bachelor's
- Master's
- Ph.D.
Salary/Compensations
- $131,400.00 - $206,800.00
Benefits
- Annual bonus
- Long-term incentive
- Medical, dental, vision healthcare and other insurance benefits (for employee and family)
- Retirement benefits, including 401(k)
- Paid holidays, vacation, and compassionate and sick days
About the Company
- Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Equal Opportunity
- As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
- As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
- We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.