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About the Role

Directly support Atlas’s CMOS chip-based DNA synthesis, including both Phosphoramidite and Enzymatic workflows to support product and customer development needs. This will entail working with scientists, engineers, and business development staff on a daily basis.

Responsibilities

• Perform regular on-chip DNA synthesis runs for customers, encompassing reagent preparation, chip handling, extraction of DNA, and post extraction PCR, Aliquoting and encapsulation
• Lead operation of all hardware and manage limited scale production, growing team as business demands.
• Develop and help analyze QC data, utilize data to ensure that completed samples are all of adequate quality before shipment.
• Develop and implement SOPs for production process.
• Train and manager RAs and Operators to execute the SOPs effectively.
• Develop processes to reduce turnaround time and optimize production.

Requirements

• Prior experience with custom instrumentation within a workflow: running experiments to characterize either the instrument, chip, or other modules involved in the process.
• Comfortable in learning to operate new hardware.
• Experience in using a range of automated liquid handlers
• Experience in research or production of solid phase oligonucleotide (DNA) synthesis (phosphoramidite and/or enzymatic)
• Experience with laboratory techniques including DNA characterization (Qubit, Nanodrop, Bioanalyzer, CE), PCR, qPCR, LCMS, NGS, DNA hybridization assay experience -preferred
• Knowledge of silicon processing techniques or electrochemistry – a plus
• Understanding of micro-scale processes, physics, chemistry, surface chemistry development – a plus
• Self-learner, self-starter, with the ability to grasp concepts and techniques on the go.
• Desire to wear multiple hats within a small unit and develop a well-rounded multi-disciplinary profile.
• Experience in effectively managing and training small groups of research associates and operators to develop and maintain production efficiency while ensuring compliance with SOPs and need procedures.

Skills

• DNA synthesis
• Phosphoramidite workflow
• Enzymatic workflow
• Reagent preparation
• Chip handling
• DNA extraction
• PCR
• Aliquoting
• Encapsulation
• Hardware operation
• QC data analysis
• SOP development
• Process optimization
• Automated liquid handlers
• Solid phase oligonucleotide synthesis
• DNA characterization
• Qubit
• Nanodrop
• Bioanalyzer
• CE
• qPCR
• LCMS
• NGS
• DNA hybridization assay
• Silicon processing techniques
• Electrochemistry
• Micro-scale processes
• Physics
• Chemistry
• Surface chemistry development
• Team management
• Training

Experience Level

• 5 plus years work experience in an industry setting is desirable

Education Level

• Bachelor’s degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Chemistry, Molecular Biology or other relevant field.