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About the Role
You will be a founding member of Capable Labs’ RNA program, playing a mission-critical role in building this capability. This is an opportunity for steep learning and rapid growth, with the potential for your role to evolve significantly every few months based on your judgment and performance. You will be entrusted with context, trust, and resources to move quickly.
Responsibilities
- Design ASOs, siRNAs, splice-switching oligos, gapmers, steric-blocking oligos, and other RNA-targeting molecules against key targets.
- Select oligo chemistry based on tissue, mechanism, potency, durability, and safety.
- Develop core sequence strategies for various RNA-level mechanisms.
- Build and refine design rules around potency, specificity, GC content, secondary structure, and other factors.
- Source, synthesize, purify, and quality control oligos using various analytical techniques.
- Run in vitro validations including cell uptake, dose response, target knockdown, and RNA-seq/qPCR.
- Evaluate developability, including serum stability, solubility, and immune activation.
- Design in vivo studies to measure exposure, tissue distribution, and target engagement.
- Analyze PK/PD and efficacy data to inform next steps.
- Build the full ASO program package, including target rationale, sequence set, and experimental results.
Requirements
- Hands-on experience with RNA therapeutics, ASOs, siRNA, splice-switching oligos, RNA biology, nucleic acid chemistry, pharmacology, or closely related work.
- Ability to reason from target biology to oligo design to assay readout.
- Comfortable designing and interpreting assays that validate RNA therapeutics.
- Experience with qPCR, ddPCR, RNA-seq, western blot, ELISA, reporter assays, splice assays, cytokine panels, or tissue analysis is helpful.
- Ability to work efficiently while maintaining scientific rigor.
- Proactive and resourceful in moving work forward.
Skills
- ASO design
- siRNA design
- Splice-switching oligo design
- RNA biology
- Nucleic acid chemistry
- Pharmacology
- Assay design and interpretation
- qPCR
- ddPCR
- RNA-seq
- Western blot
- ELISA
- Reporter assays
- Splice assays
- Cytokine panels
- Tissue analysis
- HPLC/UPLC
- LC-MS
- MALDI
- UV quantification
- PAGE
- Endotoxin/bioburden testing
Location
- San Francisco
Work Type
- Onsite
Experience Level
- Founding member
- Early-stage team member
Salary/Compensations
- $135,000–$180,000
Benefits
- $50,000–$200,000 worth of equity options
- Compensation based on qualifications, skills, competencies, and experience
- Visa sponsorship available
- $500+ per month wellness budget
- Comprehensive healthcare coverage
About the Company
- Capable Labs is building an RNA program.