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About the Role

We are seeking a Discovery Program Leader (DPL) to represent Nonclinical Drug Safety (NDS) on discovery research teams and in scientific and strategic review meetings focused primarily on immunology and oncology. This position requires exceptional leadership, collaboration, and independence, and a passion to work collaboratively across functions and sites to discover novel medicines that improve the lives of patients.

Responsibilities

Defining and overseeing the NDS strategy for programs in all modalities from Target Identification through to the approval of First-In-Human enabling GLP toxicity studies.
Providing risk assessments for targets.
Developing de-risking strategies for discovery programs.
Collaborating with NDS staff at other sites to execute appropriate studies to support selection of therapeutic targets, and the identification and development of new drug candidates.
Serving on development teams with responsibility for defining the GLP toxicology study strategy and execution.
Overseeing non-clinical safety sections of regulatory documents that support clinical trials and worldwide marketing authorization.
Representing NDS on discovery teams and participating in therapeutic area discovery governance committee reviews.
Promoting and facilitating creative thinking from target identification/validation through lead optimization, primarily in the Immunology Therapeutic Area, but also Oncology, Cardiometabolic, Infectious Disease and/or Neuroscience Therapeutic Areas.
Acting as a “drug creator” and promoter of innovative thinking by influencing both cross-site disease area aligned groups, as well as functional area disciplines.
Identifying and assessing potential risks associated with therapeutic targets or development candidates using available literature, internal data, and external information.
Leading early development teams, informing on preclinical studies to support product development.

Requirements

PhD in Toxicology, Pharmacology, Pathology, Biology, Biochemistry, Immunology, Pharmaceutical Sciences, Chemistry, or related STEM field, DVM, MD degree or equivalent.
Minimum 8+ years of demonstrated pharmaceutical industry experience as a non-clinical safety scientist (e.g. Toxicology, Pathology etc.) and/or as non-clinical safety assessment representative to a cross-functional development and/or discovery teams.
Demonstrated ability to successfully navigate cross-functional lines and drive team decision making in a matrix organizational structure.
Highly dedicated, motivated, resilient, and flexible; capable of creative problem solving and delivering on goals and objectives in a timely fashion.
Excellent team player who can work collaboratively with discovery team members from various functions, other DPLs and scientists responsible for study conduct and portfolio management.
Excellent interpersonal skills, able to establish good working relationships within networks of employees of all levels.
Excellent communicator who knows when and how to speak up, and appropriately raise issues to stakeholders and to management.
Background in immunology is preferred.
Experience with biopharmaceutical and small molecule pharmaceutical development and/or discovery.
Experience with regulatory submissions and responses.
Member of pharmaceutical consortia and/or external scientific or professional organizations.

Skills

Adaptability
Combination Products
Drug Development
Drug Discovery Process
Immunology
Immunotherapy
Innovative Thinking
Oncology
Professional Collaboration
Professional Networking
Safety Evaluation
Strategic Thinking
Toxicology

Location

US and Puerto Rico Residents Only

Work Type

Hybrid
Regular

Experience Level

Principal Scientist, Nonclinical Drug Safety Program Discovery - Equivalent in level to Scientific Director
8+ years of demonstrated pharmaceutical industry experience

Education Level

PhD in Toxicology, Pharmacology, Pathology, Biology, Biochemistry, Immunology, Pharmaceutical Sciences, Chemistry, or related STEM field, DVM, MD degree or equivalent.

Salary/Compensations

$176,200.00 - $277,300.00

Benefits

Eligible for annual bonus and long-term incentive, if applicable.
Comprehensive package of benefits.
Medical, dental, vision healthcare and other insurance benefits (for employee and family).
Retirement benefits, including 401(k).
Paid holidays, vacation, and compassionate and sick days.

About the Company

Our company is a global health leader with a diversified portfolio of prescription medicines, vaccines and animal health products.
The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century.
Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Equal Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.