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About the Role

AbbVie is seeking a highly talented and motivated Senior Scientist I to join our siRNA therapeutics team within Biotherapeutics and Genetic Medicine (BGM) at the South San Francisco (ABA) site. The successful candidate will lead in vitro discovery biology efforts to support the development of innovative siRNA-based medicines for oncology. This individual will design and execute experiments, drive scientific innovation, collaborate across multidisciplinary teams, and contribute to advancing therapeutic candidates from early discovery through development candidate nomination for oncology programs.

Responsibilities

Lead and execute in vitro siRNA discovery and proof-of-concept activities, including target validation, assay development and optimization, siRNA screening, lead optimization, and mechanism-of-action studies to support active therapeutic programs for oncology.
Develop, validate and execute robust siRNA-based in vitro screening funnels for hit-to-lead identification to support siRNA-based drug discovery projects (e.g. 96 well RNA isolation, qPCR, westerns, ELISA, flow cytometry, reporter assays, RNA-seq, microscopy and others).
Identify and resolve key biological and technical pitfalls related to siRNA activity, delivery, stability, and on-target and off-target effects.
Maintain updated and well-organized ELNs and ensure high scientific rigor, reproducibility, and data integrity.
Author internal technical reports and regulatory documents, and contribute as primary author on conference proceedings, manuscripts, and/or inventor of patents.

Requirements

BS, MS, or PhD in cell biology, molecular biology, biochemistry, pharmacology or related field with typically 0-3 (PhD), 8+ (MS), or 10+ (BS) years of relevant experience.
RNA biology/therapeutics industry or postdoctoral experience preferred.
Strong hands-on experience with molecular biology techniques (e.g. stem-loop RT-qPCR and RT-qPCR), including assay design, optimization, validation, and data interpretation for siRNA quantification and mRNA target knockdown.
Extensive experience with mammalian cell culture and transfection techniques.
Experience working with animal tissues would be a plus.
Demonstrate ability to learn, understand and master new experimental techniques.
Strong data analysis and critical thinking abilities.
Routinely demonstrate scientific initiative and creativity in research or development activities.
Excellent written and verbal communication skills, attention to detail, multi-tasking and organizational skills, and the ability to collaborate effectively with a team.
Strong presentation skills with the ability to clearly articulate scientific findings and project updates to project teams, senior leadership, and external stakeholders.
Highly independent and productive in performing laboratory research or assay development, requiring only minimal direction from or interaction with supervisor.
Familiarity with tumor intrinsic biology and/or immune oncology.
Experience working with tumor models would be a plus.
Experience with extrahepatic oligonucleotide delivery technologies, particularly antibody–oligonucleotide conjugates (AOCs), is highly desirable.
Strong publication track record.
Ability to work in fast-paced, collaborative environment.

Skills

RNA interference (RNAi) biology
siRNA discovery
Target validation
Assay development
Assay optimization
siRNA screening
Lead optimization
Mechanism-of-action studies
siRNA-based in vitro screening
Hit-to-lead identification
RNA isolation
qPCR
Westerns
ELISA
Flow cytometry
Reporter assays
RNA-seq
Microscopy
Mammalian cell culture
Transfection techniques
Molecular biology techniques
Stem-loop RT-qPCR
RT-qPCR
Data analysis
Critical thinking
Scientific initiative
Scientific creativity
Written communication
Verbal communication
Attention to detail
Multi-tasking
Organizational skills
Collaboration
Presentation skills
Laboratory research
Assay development
Tumor intrinsic biology
Immune oncology
Oligonucleotide delivery technologies
Antibody–oligonucleotide conjugates (AOCs)

Location

South San Francisco (ABA) site

Work Type

Full-time

Experience Level

Senior Scientist I
0-3+ years (PhD)
8+ years (MS)
10+ years (BS)

Education Level

Salary/Compensations

USD 96500 - USD 183500 - yearly

Benefits

Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Short-term incentive programs

About the Company

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.
We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio.
Within the Biotherapeutics and Genetic Medicine (BGM) organization, the newly established siRNA team is building and advancing therapeutic programs from early discovery through development, applying rigorous biology, innovative experimental approaches, and data-driven decision-making to deliver differentiated RNA medicines.
AbbVie offers a collaborative, science-focused environment where discovery scientists play a direct role in shaping therapeutic programs.
You will have the opportunity to work alongside leading research scientists and cutting-edge siRNA medicines and contribute to advancing next generation therapies that make an impactful difference for patients.

Equal Opportunity

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.
Equal Opportunity Employer/Veterans/Disabled.