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About the Role

Seeking entrepreneurially-minded scientists with deep technical expertise to solve durable and consequential challenges in medicine through venture building. This role offers a unique opportunity to work at the forefront of CNS drug delivery, leading a company that makes it fundamentally easier, safer, and more broadly applicable to get therapeutics into the brain.

Responsibilities

• Refine, improve, and complement existing scoping work on the technical thesis for approaches that dramatically improve the efficiency, safety, and modality breadth of drug delivery across the blood-brain barrier.
• Develop IP strategy, differentiation, and competitive analysis.
• Conduct market analysis, value capture, and techno-economic assessments.
• Define regulatory strategy and positioning.
• Formulate fundraising strategy and pitching.
• Optimize company strategy for the most rapid and de-risked path to Series A.
• Fulfill investment criteria, recruit advisory and co-founding team members, and conduct parallel fundraising for additional expansion funds.
• Lead the spin-out of a new company within the CNS drug delivery space.
• Provide tailored guidance, resources, and feedback covering technical and commercial aspects of launching a new venture.
• Utilize optimized, purpose-built, proprietary tools, resources, and processes for venture creation.
• Leverage DSV and Partners' extensive network, technical, commercial, and fundraising expertise.
• Provide continuous support post spin-out, including fundraising, commercial partnerships, recruitment, and team-building.

Requirements

• Deep expertise in at least two of the following four areas: Protein Engineering, Biologics Drug Development, Cell Biology & Neurobiology, Medicinal Chemistry.
• Track record of translating scientific concepts from discovery through to in vivo proof-of-concept or IND.
• Experience managing CRO/CDMO or Pharma programs and building regulator- or investor-ready data packages.
• Highly motivated by unsolved challenges in CNS drug delivery and driven to challenge the status quo.
• Impact driven, takes initiative, makes things happen, and can think from a first principles perspective.
• Clear entrepreneurial spirit and mindset, demonstrated through impactful innovation.
• Ability to work in ambiguous, unstructured, fast-paced, demanding, and pressurized environments.
• Collaborative nature, with the ability to work effectively in cross-functional teams.

Skills

• Protein Engineering
• Protein design
• Structural analysis
• Sequence motif analysis
• Lead generation campaigns
• Screening cascades
• Computational modelling
• AI/ML tools
• Antibody lead generation (in silico or immunisation)
• Antibody optimisation
• Synthetic biology (mini proteins, cell-penetrating peptides, endosomal escape peptides, membrane insertion peptides)
• Biologics Drug Development
• Diverse modalities (bispecific antibodies, protein fusions, antibody conjugates, Fc engineering, synthetic proteins, macrocyclic peptides)
• Discovery & pre-clinical development (target ID, target validation, lead generation, lead optimisation, DC, IND)
• Developability (PK/PD, ADME, Toxicology, CMC)
• In vitro and in vivo pharmacology and study design for protein biologics
• Cell Biology & Neurobiology
• Intracellular trafficking
• Endocytosis
• Adaptor proteins
• Endosomal sorting
• Tubule formation
• Kinesin transport
• Blood-brain barrier biology
• Endothelial cell biology
• Transcytosis
• Receptor-mediated transcytosis (RMT)
• Carrier-mediated transcytosis (CMT)
• CNS disease biology (AD, PD, MS, and other neurological conditions)
• Human BBB translational models (e.g. in vitro iPSC-derived BBB models)
• Medicinal Chemistry
• Small molecule conjugates
• Cleavable linkers
• Molecular glues
• Degraders
• CNS-penetrant small molecule design
• Efflux transporter biology
• CNS preclinical or clinical drug development experience
• Single-cell transcriptomic data analysis
• Target & biomarker identification
• Intellectual Property (IP) - FTO and patentability
• Track record of patents in CNS delivery or related fields
• Track record of publications and/or thought leadership in CNS delivery or related fields
• Biotech founder or C-suite leadership experience
• Fundraising experience (VC, dilutive or non-dilutive)
• Building and leading successful scientific or cross-functional teams
• Network across CNS pharma, biotech, or relevant academic institutions

Location

• Remote initially
• Location TBD post spin-out

Work Type

• Full-time
• Remote

Experience Level

• Founder-in-Residence
• Entrepreneurial
• Deep technical expertise

Education Level

• PhD (preferred)

Salary/Compensations

• Minimum guaranteed income of £4,166 per month (fixed) as a consultancy fee until company launch and pre-seed investment is secured.

Benefits

• Pre-seed investment of £250k (~$330k / €290k) upon successful IC approval.
• Significant equity stake in the spun-out company.
• Continuous support post spin-out.
• Access to DSV's venture creation methodology, tools, and resources.
• Access to DSV and Partners' extensive network.
• Collaboration with other Founders at DSV.

About the Company

• Deep Science Ventures (DSV) is on a mission to create a future in which both humans and the planet can thrive.
• DSV uses a unique venture creation process to create, spin-out, and invest in science companies.
• DSV combines available scientific knowledge and founder-type scientists into high-impact ventures.
• DSV operates in four sectors: Pharmaceuticals, Climate, Agriculture, and Computation.
• DSV tackles defining challenges through a first principles approach and partnerships with leading institutions.
• Medicines Discovery Catapult (MDC) provides deep domain expertise, translational infrastructure, and a network of KOLs, CROs, and pharma relationships.