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About the Role

Lead translational strategy across a fast-moving portfolio in B-ALL, B-CLL and NHL, connecting mechanism to medicine across multiple modalities. Shape the biomarker vision that drives dose, patient selection and combination choices from first-in-human through pivotal studies. Partner closely with discovery scientists, clinicians and diagnostics experts to build translational data packages that change clinical trajectories. Own end-to-end translational strategies for assigned B-cell malignancy programs from preclinical through Phase 1/2 and, as needed, Phase 3, with clear decision points tied to dose, schedule and patient selection.

Responsibilities

Integrate human genetics, expression and clinical data to define indications, stratify patients and refine target populations across monotherapy and rational combinations.
Design and interpret target engagement and pharmacodynamic biomarker readouts to enable data-driven dose selection and early proof of mechanism across multiple concurrent studies.
Define and investigate mechanisms of resistance using longitudinal and relapse samples to inform next-line strategies and combination hypotheses.
Analyze B-cell tumor biology, pathway interactions and microenvironment features in patient samples to guide combination design and strengthen translational rationale.
Lead development, validation and deployment of fit-for-purpose assays internally and with external labs/CROs, aligned to clinical endpoints and timelines.
Embed biomarker strategies and endpoints into protocols, sample manuals and statistical plans; partner with biosamples and precision diagnostics to ensure collection, traceability and, where relevant, CDx path alignment.
Represent Translational Medicine on cross-functional teams, connect insights across the B-cell portfolio to inform indication expansion and combinations, and contribute to governance materials, study reports and Go/No-Go recommendations.
Contribute translational and biomarker content for health authority interactions and filings; build coherent scientific narratives; present internally and in external forums to shape the field in B-cell translational research.

Requirements

PhD in a relevant biological science (hematology-oncology, immunology, oncology, molecular biology, or related field); postdoctoral and/or industry experience required.
Demonstrated experience with T-cell engaging bispecifics in an oncology/hematology development context.
Demonstrated experience with antibody-drug conjugates (ADCs) in a hematology or oncology development context.
Experience contributing to early phase oncology clinical trials, including biomarker plan development, protocol input, and sample analysis; exposure to Phase 3 trial biomarker strategies a plus.
Demonstrated expertise in biomarker technologies such as flow cytometry, immunohistochemistry, molecular profiling, NGS, ctDNA, MRD assessment, cytokine/immune profiling, and other omics-based approaches as relevant to hematologic cancers.
Established knowledge of B-cell malignancy biology spanning leukemia (B-ALL, B-CLL) and lymphoma (NHL), including disease pathogenesis, standard-of-care landscape, and mechanisms of therapeutic resistance.
In-depth understanding of immunology and the tumor microenvironment in B-cell cancers, with ability to apply this knowledge to translational strategy and biomarker design.
Emerging understanding of the end-to-end clinical development process — from dose escalation through registration — and the strategic role of biomarkers at each stage.
Ability to work independently and deliver translational programs with regular managerial support; demonstrates sound scientific judgment and prioritization without close oversight.
Proven ability to operate effectively and demonstrate scientific leadership within cross-functional program teams in a matrixed pharma or biotech environment; understands the roles of Clinical, Ops, Project Management, and HBS Clinical functions in delivering translational work.
Clearly presents and integrates scientific data across experiments to support a cohesive program narrative; able to articulate the implications of translational findings for Go/No-Go decisions with emerging clarity on risks and caveats.
Excellent communication and presentation skills for internal stakeholders and emerging external scientific audiences; comfortable representing TM in cross-functional governance settings.
Emerging awareness of broader AZ functions (Regulatory, Medical, Commercial) and how TM outputs interface with and inform those stakeholders.
Experience with small molecule hematology therapeutics in B-cell malignancies (e.g., BTK inhibitors, BCL-2 inhibitors) and familiarity with combination treatment strategies.
Exposure to cell therapy programs (CAR-T or other engineered cell therapies) in B-cell leukemia or lymphoma.
Familiarity with Minimal Residual Disease (MRD) methodologies (flow cytometry and/or NGS-based) in leukemia or lymphoma clinical development.
Experience integrating multi-omic biomarker data (flow cytometry, ctDNA, cytokine panels, transcriptomics) to support clinical decision-making across combination regimens.
Familiarity with regulatory expectations for biomarker analytical validation and CDx development.
Early experience mentoring junior scientists; interest in contributing to team capability development.

Skills

B-cell malignancy biology
Translational strategy
Biomarker vision
Dose selection
Patient selection
Combination choices
Mechanism to medicine
T-cell engaging bispecifics
ADCs
Small molecules
Cell therapies
Human genetics
Expression data
Clinical data integration
Target engagement
Pharmacodynamics
Resistance biology
Tumor microenvironment
Flow cytometry
IHC/IF
Molecular assays
MRD assessment
Clinical trial design
Protocol development
Sample analysis
Cross-functional team leadership
Scientific communication
Presentation skills
Regulatory filings
BTK inhibitors
BCL-2 inhibitors
CAR-T
NGS
ctDNA
Cytokine profiling
Omics-based approaches
CDx development

Location

Gaithersburg, MD
South San Francisco, CA

Work Type

Hybrid

Experience Level

Associate Director
Postdoctoral experience
Industry experience
Early phase clinical trial experience
Phase 3 trial biomarker strategy exposure
Emerging understanding of clinical development
Early experience mentoring junior scientists

Education Level

PhD in a relevant biological science (hematology-oncology, immunology, oncology, molecular biology, or related field)

Salary/Compensations

$142,377.60 - $213,566.40 USD Annual

Benefits

Eligibility for various incentives
Short-term incentive bonuses
Equity-based awards for salaried roles
Commissions for sales roles
Qualified retirement programs
Paid time off (i.e., vacation, holiday, and leaves)
Health, dental, and vision coverage

About the Company

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company.
We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases.
We are dedicated to being a Great Place to Work.
Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit.
To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges.
There is no better place to make a difference in medicine, patients, and society.
An inclusive culture where you will connect different thinking to generate new and valuable opportunities.
Where you will find a commitment to lifelong learning, growth and development for all.
Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients.
Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking.
We’re curious about science and the advancement of knowledge.
We find creative ways to approach new challenges.
We’re driven to make the right choices and be accountable for our actions.
As an organisation centred around what makes us human, we put a big focus on people.
Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab.
Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential.
Here, you’ll do work that has the potential to change your life and improve countless others.
And, together with your team, you’ll shape a culture that unites and inspires us every day.
This is your life at AstraZeneca.

Equal Opportunity

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees.
In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics.
If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.