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About the Role

Seeking a motivated Oligonucleotide Scientist II to support oligonucleotide therapeutic discovery within a collaborative drug discovery team. The successful candidate will have hands-on experience in oligonucleotide synthesis, purification, and characterization, and will contribute to the development of RNA-based therapeutics across neuroscience, oncology, and immunology programs.

Responsibilities

• Perform hands-on synthesis, purification, and characterization of oligonucleotides using automated synthesizers, HPLC, and mass spectrometry.
• Develop, optimize, and troubleshoot oligonucleotide synthesis methods, including impurity profiling and process improvements.
• Collaborate with cross-functional research teams to support oligonucleotide therapeutic discovery and lead molecule progression.
• Operate, maintain, and troubleshoot laboratory equipment including oligo synthesizers, HPLC systems, and desalting units.
• Execute nucleic acid chemistry experiments, analyze data, maintain laboratory documentation, and support scale-up synthesis for preclinical studies.
• Conduct literature reviews and contribute to experimental planning, scientific discussions, and project presentations.
• Maintain high laboratory productivity while adhering to safety and quality standards.

Requirements

• BS or MS in Organic Chemistry, Medicinal Chemistry, Biochemistry, Chemical Biology, or a related scientific discipline.
• Hands-on experience with automated oligonucleotide synthesis.
• Experience with HPLC purification and mass spectrometry for oligonucleotide characterization.
• Knowledge of nucleic acid chemistry and oligonucleotide synthesis workflows.
• Strong analytical, troubleshooting, organizational, and communication skills.
• Ability to work independently and collaboratively in a fast-paced research environment.
• Experience in RNAi therapeutics, antisense oligonucleotides (ASO), or nucleic acid therapeutics.
• Experience with large molecule drug discovery, oligonucleotide delivery, or bioconjugation.
• Knowledge of sequence design, nucleic acid modifications, and therapeutic mechanisms of action.
• Pharmaceutical or biotechnology industry experience in oligonucleotide drug discovery.
• Experience supporting preclinical research and scale-up synthesis.

Skills

• Oligonucleotide Synthesis
• Automated Oligo Synthesizers
• RNAi / RNA Therapeutics
• Nucleic Acid Chemistry
• HPLC Purification
• Mass Spectrometry (LC-MS)
• Oligonucleotide Characterization
• Impurity Profiling & Troubleshooting
• Organic Synthesis

Location

• South San Francisco

Work Type

• Long term contract

Experience Level

• Scientist II

Education Level

• BS or MS in Organic Chemistry, Medicinal Chemistry, Biochemistry, Chemical Biology, or a related scientific discipline.

Salary/Compensations

• $53.50/hr

About the Company

• Leading leader in biotechnology and diagnostics.