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About the Role

We are seeking an accomplished Senior Scientist of Macrophage Biology to provide scientific leadership in macrophage biology and immune-stromal interactions, driving target identification, validation, and translational strategy across our fibrosis and oncology discovery portfolio. You will establish macrophage-based target screening assays combined with novel extracellular matrix-based cell models, utilizing cellular, immunological, biochemical, molecular biology, and functional genomic approaches. You will also provide scientific mentorship and technical guidance, champion innovative approaches, and represent macrophage biology expertise within cross-functional project teams.

Responsibilities

Establish a suite of macrophage functionality assays for target discovery and drug discovery, including activation, cytokine secretion, phagocytosis, and efferocytosis assays.
Optimize macrophage target screening-based systems using annotated lmw libraries and functional genomic approaches such as siRNA and CrispR library-based approaches.
Lead a small team of immunologists/cell biologists involved in project execution across internal and external biopartnerships.
Lead the build of novel macrophage drug target nomination packages and present cases to leadership for portfolio entry.
Analyze, interpret, report, and present results.

Requirements

Demonstrable expertise in macrophage biology, particularly phagocytosis pathways.
Demonstrable experience in target nomination and validation in a biotech or pharmaceutical setting.
Expertise in the use of multi-colour flow cytometry and IF techniques.
Hands-on experience with key immunological and molecular biology techniques including MSD, RNA/DNA extraction, qRT-PCR, western blotting, and siRNA knockdown.
Team and direct people leadership experience.
Familiarity with molecular pharmacology and oncology drug development is an advantage.
Prior working experience in the biotech/pharma industry performing laboratory research is a further plus.
Ability to plan, execute, and critically assess experiments independently.
Excellent time-management skills and ability to work to set deadlines.
Ability to work well within a team.
Strong written and verbal communication skills.
IT skills.
Ability to troubleshoot effectively.
Ability to work methodically.
Ability to stay well organized.
Ability to pay close attention to detail.
Ability to maintain accurate records.

Skills

Macrophage biology
Immune-stromal interactions
Target identification
Target validation
Translational strategy
Fibrosis
Oncology
Macrophage-based target screening assays
Extracellular matrix-based cell models
Cellular approaches
Immunological approaches
Biochemical approaches
Molecular biology approaches
Functional genomic approaches
Scientific mentorship
Technical guidance
Innovative approaches
Emerging technologies
Cross-functional project teams
Macrophage functionality assays
Activation assays
Cytokine secretion assays
Phagocytosis assays
Efferocytosis assays
Macrophage target screening
Annotated lmw libraries
siRNA
CrispR library-based approaches
Drug target nomination
Data analysis
Data interpretation
Results reporting
Results presentation
Phagocytosis pathways
Multi-colour flow cytometry
IF techniques
MSD
RNA extraction
DNA extraction
qRT-PCR
Western blotting
siRNA knockdown
Molecular pharmacology
Oncology drug development
Laboratory research
Biomedical sciences
Immunology
Biochemistry
Biotechnology
Immuno-oncology
Experiment planning
Experiment execution
Critical assessment
Time management
Teamwork
Communication skills
IT skills
Troubleshooting
Methodical work
Organization
Attention to detail
Record keeping

Location

White City Place, West London

Work Type

Full-time

Experience Level

Senior
4 years’ experience in drug screening setting
8 years practical experience

Education Level

PhD in Biomedical sciences, Immunology, Biochemistry, Biotechnology or related discipline
MSc

Benefits

Private medical insurance
Pension
Bonus
Employee perks

About the Company

Engitix is a growing biotech company based in White City Place, West London.
We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform.
Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates.
Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.