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About the Role
Denali Therapeutics is seeking an Associate Scientist to join the Purification Process Development team. The role focuses on supporting late-stage downstream process development activities for a large molecule pipeline, aiming to deliver breakthrough therapies for neurodegenerative diseases.
Responsibilities
- Support purification process characterization, validation, PPQ and BLA-enabling activities.
- Monitor process performance and trend data.
- Coordinate sample handling from GMP manufacturing campaigns.
- Extract and organize data for report and submission authoring.
- Contribute to statistical analysis.
- Support tech transfer and GMP campaign readiness.
- Execute lab-scale chromatography and filtration studies to inform late-stage data packages.
- Execute in-process testing using ELISA, HPLC, UV and SDS-Page based analytics.
- Summarize key experimental data and document all experiments in an electronic lab notebook.
- Collaborate with colleagues in CMC, Discovery and other functions to achieve project goals.
Requirements
- BS/MS in Biology, Biochemistry, Chemical Engineering or related scientific discipline.
- 3+ years of industry experience.
- Experience in protein characterization, design of experiments and analytics.
- Experience monitoring downstream GMP and/or pilot production unit operations.
- Hands-on experience with AKTA protein purification systems, lab-scale TFF systems and antibody characterization methods including: HPLC, LC/MS, SDS‐PAGE, DLS and other biophysical techniques.
- Excellent critical thinking, scientific problem-solving and communication skills.
- Prior experience in a late-stage process development setting is preferred.
Skills
- Protein characterization
- Design of experiments
- Analytics
- ELISA
- HPLC
- UV
- SDS-Page
- AKTA protein purification systems
- Lab-scale TFF systems
- LC/MS
- DLS
- Biophysical techniques
- Statistical analysis
Location
- Not specified
Work Type
- Not specified
Experience Level
- 3+ years of industry experience
- Associate Scientist
Education Level
- BS/MS in Biology, Biochemistry, Chemical Engineering or related scientific discipline
Salary/Compensations
- $106,000.00 to $138,000.00
Benefits
- 401k
- Healthcare coverage
- ESPP
About the Company
- Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through deep commitment to degeneration biology and principles of translational medicine.
- Founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
- Life at Denali is a living reflection of our values: trust, unity, grit and growth.
Equal Opportunity
- Denali is proud to be an equal opportunity employer and does not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.