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About the Role

The Senior Applications Manager is responsible for owning and overseeing a portfolio of enterprise applications, including General GxP and non-GxP systems and their integrations, ensuring they deliver reliable, high-quality, secure, and cost-effective outcomes. This role provides strategic direction to service delivery teams, maintains oversight of application health, and establishes governance frameworks for continuous improvement in a Business As Usual environment.

Responsibilities

Support Oversight (via Service Delivery)
Partner with Service Delivery Managers (SDMs) and support teams to ensure strong application support performance
Define expectations for support quality, SLAs, and user experience
Review incident trends and ensure systemic issues are identified and resolved
Hold vendors and support teams accountable for outcomes, not just activity
Business Partnering and Demand Prioritization
Work closely with Business Stakeholders (BSOs) to understand day-to-day operational needs
Translate needs into a prioritized backlog based on business impact and urgency
Make clear trade-offs across competing demands and limited capacity
Ensure delivery is high quality and cost-conscious, not just fast
Financial Ownership & Optimization
Own budget for applications, including licenses, vendors, and run costs
Identify and drive opportunities for cost optimization and efficiency
Ensure the application landscape scales in a financially sustainable way as the business grows
Manage renewals, contracts, and commercial negotiations
Vendor & Contract Management
Manage third-party vendors and partners delivering support and enhancements
Negotiate and manage contracts, scope, and commercial terms
Ensure vendors are delivering value for money and meeting expectations
Drive accountability and performance improvements where needed
Data-Driven Decision Making
Use data (ticket trends, usage metrics, cost data, performance metrics) to guide decisions
Continuously reassess priorities and approaches based on new information
Be willing to challenge assumptions and adjust direction when needed
Integration & System Landscape Oversight
Maintain visibility across integrations between systems (e.g., CRM ↔ ERP ↔ HRIS)
Ensure changes are considered in the context of the broader application ecosystem
Work with technical teams to manage dependencies and avoid downstream issues

Requirements

7–12+ years working with enterprise applications (General GxP and non-GxP systems)
Experience owning or managing application portfolios, not just individual systems
Strong experience managing third-party vendors and commercial relationships
Experience working in environments with separate support/service delivery functions
Experience in regulated industries (e.g., pharma, biotech, healthcare) (P)
Familiarity with compliance requirements (e.g., GxP, SOX) (P)
Experience with systems such as Salesforce, Dynamics 365, Workday, or similar (P)

Skills

Strong ability to prioritize and make trade-offs across competing business needs
Comfortable operating with budget ownership and cost accountability
Data-driven mindset with the ability to turn insights into action
Excellent stakeholder management and influencing skills
Ability to operate across both business and technical contexts

Location

Mediaworks (London)
Hybrid working

Work Type

Hybrid working

Experience Level

7-12+ years

Education Level

Bachelor’s degree in Information Technology, Computer Science, Business Information Systems, or a related discipline (P)
Equivalent professional experience may be accepted in place of a degree

Salary/Compensations

Competitive salary
Performance related bonus

Benefits

Private medical insurance
Life assurance
Pension

About the Company

Autolus is a biopharmaceutical company, advancing innovative therapies at both clinical and commercial stages of development, focused on next-generation, programmed T cell therapies for the treatment of cancer.
Using a broad suite of proprietary and modular T cell programming technologies, the company is engineering precisely targeted, controlled, and highly active T cell therapies designed to better recognize cancer cells, break down their defence mechanisms, and eliminate these cells.
Autolus has a pipeline of product candidates in development for the treatment of haematological malignancies, solid tumours, and autoimmune diseases.
Our team is passionate in the pursuit of excellence and in pushing the boundaries of cancer therapy and autoimmune diseases to deliver life-changing treatments to patients.
Whilst working at Autolus you will enjoy a flexible, diverse, and dynamic working environment which actively promotes creativity, leadership and teamwork.
Autolus is developing complex, breakthrough therapies for a globally diverse market and equally recognises that diversity amongst our people is critical to our mission.
As we draw on our differences, what we’ve experienced, and how we work, we celebrate diversity and are committed to creating an inclusive environment for all employees.
Autolus’ success is driven by equality and inclusion; we believe all voices are of equal value and must be heard.
Whilst operating with focus and integrity, we are committed to improving diversity and inclusion within our business and our industry.

Equal Opportunity

Autolus is committed to providing an inclusive and fair workplace for all.
We are an equal opportunity employer and do not discriminate on the basis of race, colour, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic.
We also provide reasonable accommodations where appropriate.
We also provide reasonable accommodations throughout the recruitment process.