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About the Role

As a Principal Engineer, you will be a hands-on contributor with exemplary engineering skills and the ability to think strategically to define architectural directions. You will be a problem-solver who identifies risks, issues, gaps, and dependencies, bringing people together to find solutions through supportive, empathetic, and collaborative behaviors. You will consciously balance immediate team goals against long-term product direction.

Responsibilities

Work alongside product managers, squad engineers, bioinformaticians, and other subject matter experts to continuously evolve a roadmap for change.
Act as the voice of technical excellence, ensuring continuous improvement of functional, safety, and operational characteristics of products.
Stay abreast of emerging technologies and industry trends, incorporating them into software development practices.
Contribute to the wider conversation at Genomics England and help mature technical practices.

Requirements

Strong software engineering skills and awareness of software design patterns (Python preferred, Typescript/React desirable, polyglot ideal).
Knowledge of different database types and their applicability (Postgres/Aurora, MongoDB, and Elastic/OpenSearch are in use).
Experience shaping and guiding architectural choices, both tactical and long-term.
Experience of API schema design and evolution.
DevOps experience (CI/CD, Infrastructure as Code, operational monitoring and alerting).
Experience in at least one major public cloud (AWS preferred).
Strong interpersonal skills with a temperament that builds trust and connection through open, honest communication.
Comfortable engaging responsively with teams both remotely and in person.
Ability to navigate rapidly to effective solutions through engaged and inclusive listening, clarity of thought, clear documentation, and succinct presentation.
Background in healthcare or bioinformatics is desirable.
Experience in regulated environments is desirable.
Familiarity with workflow technologies like Apache Airflow or NextFlow is desirable.
Proficiency in handling large, complex datasets using tools like Hadoop/EMR or Spark is desirable.
Successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check.
Applicants must disclose any previous offenses at point of application.

Skills

Python
Typescript
React
Postgres
Aurora
MongoDB
Elastic
OpenSearch
CI/CD
Infrastructure as Code
Operational monitoring
Alerting
AWS
API schema design
NextFlow
Apache Airflow
Hadoop
EMR
Spark
FHIR
GA4GH APIs
Terraform
GitLab
Artifactory
DataDog

Location

London
Canary Wharf
Cambridge
Leeds

Work Type

Blended working
Hybrid working
Remote working abroad (up to 30 days annually)
Fixed Term Contract

Experience Level

Principal Engineer
Proven and highly experienced

Salary/Compensations

£103,400 pa

Benefits

30 days’ holiday, plus bank holidays
Additional leave for long service
Option to apply for up to 30 days of remote working abroad annually
Blended working arrangements
Flexible working
Enhanced maternity, paternity and shared parental leave benefits
Defined contribution pension (Genomics England double-matches up to 10%)
Life Assurance (3x salary)
Give As You Earn scheme
Individual learning budgets
Support for training and certifications
Reimbursement for one annual professional subscription
Employee recognition programme
Referral scheme
Subsidised gym membership
Free Headspace account
Access to an Employee Assistance Programme
Eye tests
Flu jabs

About the Company

Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare.
Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives.
By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.
Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations.
We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.
Behind the Healthcare and Research outcomes, Genomics England delivers through designing, developing and operating complex healthcare software systems.
We're on the cusp of big changes with the real prospect of genomics becoming the fabric of everyday healthcare through the lifetime - from birth to old age.

Equal Opportunity

Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence.
We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background.
Genomics England’s policies of non-discrimination and equity and will be applied fairly to all people, regardless of age, disability, gender identity or reassignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part-time or employed under a permanent or a fixed-term contract or any other relevant factor.
Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work.
We aim to remove barriers in our recruitment processes and to be flexible with our interview processes.
Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us.