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About the Role

This role requires a leader with strong business acumen to define and execute business processes that drive complex programs through global registration and commercialization. This role will play a pivotal part in bringing innovative therapies to patients by ensuring that CMC development, manufacturing, and commercialization are executed with excellence, speed, and financial discipline.

Responsibilities

• Create and execute integrated cross-functional project plans, leading the integrated CMC strategy.
• Translate program strategy into cohesive development, manufacturing, and supply plans with clear milestones and deliverables.
• Drive cross-functional alignment in partnership with Clinical Development, Regulatory Affairs, Quality, Supply Chain, Commercial, and Finance teams.
• Guide and lead project performance, risk and financial management, and issues resolution for functional groups.
• Provide direction on requirements to meet internal and external stakeholders’ expectations.
• Ensure CMC activities are executed in lockstep with clinical timelines, regulatory milestones, and commercial launch plans.
• Serve as the CMC representative on program governance teams, influencing key decisions and trade-offs across functions.
• Develop and manage comprehensive CMC budgets, including development, manufacturing, and supply chain costs.
• Drive financial planning, forecasting, and scenario modeling to support program and portfolio decisions.
• Identify and implement cost optimization strategies without compromising quality, timelines, or regulatory compliance.
• Partner with Finance to ensure transparency, accountability, and disciplined capital allocation.
• Evaluate investment trade-offs and provide data-driven recommendations to senior leadership.
• Define 3y spending plans and hold quarterly financial updates.
• Execute a robust external manufacturing strategy, including selection, onboarding, and management of CMOs/CDMOs.
• Establish CDMO governance systems in conjunction with QA leadership such as performance metrics, and KPIs.
• Ensure accountability for delivery, quality, cost, and timelines.
• Proactively identify and mitigate risks across the external network, including capacity, quality, and supply continuity risks.
• Drive strong, collaborative partnerships while maintaining rigorous oversight and escalation processes.
• Operate as a GM for the program for CMC, accountable for delivery against timeline, cost, and quality objectives.
• Provide clear, concise communication and executive-level updates on risks, progress, and mitigation strategies.
• Build alignment across stakeholders and drive decisive, forward-looking decision-making.
• Oversee project management including timelines, budgets, invoices, reports and documentation.
• May assist with regulatory filings.

Requirements

• Advanced degree (PhD, MS, or equivalent) in Chemical Engineering, Pharmaceutical Sciences, Chemistry, or related field preferred.
• 9+ years of experience in biopharma CMC development, with increasing leadership responsibility.
• Demonstrated success leading programs through commercialization including NDA filing and launch.
• Deep expertise in CMC development, manufacturing, and regulatory requirements.
• Proven ability to lead highly cross-functional, matrixed teams.
• Strong track record of budget ownership and financial decision-making.
• Extensive experience managing CMOs/CDMOs at a strategic level, including performance governance.
• Ability to balance technical rigor with business and commercial considerations.
• Exceptional communication, influence, and leadership skills.
• Strategic thinker with strong execution discipline.
• Comfortable navigating ambiguity and complexity.
• Data-driven, with strong business and financial acumen.
• Collaborative, but decisive and accountable.
• High ownership mindset with a focus on outcomes.

Skills

• CMC development
• Manufacturing
• Regulatory requirements
• Cross-functional team leadership
• Budget ownership
• Financial decision-making
• CMO/CDMO management
• Strategic thinking
• Execution discipline
• Navigating ambiguity
• Data-driven analysis
• Business acumen
• Financial acumen
• Collaboration
• Decisiveness
• Accountability
• High ownership mindset
• Communication
• Influence
• Leadership

Location

• South San Francisco, California

Work Type

• On-site

Experience Level

• 9+ years of experience in biopharma CMC development, with increasing leadership responsibility.

Education Level

• Advanced degree (PhD, MS, or equivalent) in Chemical Engineering, Pharmaceutical Sciences, Chemistry, or related field preferred.

Salary/Compensations

• $210,000-$260,000

About the Company

• ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer.
• ORIC’s clinical stage product candidates include (1) rinzimetostat (ORIC-944), an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers.
• Beyond these two product candidates, ORIC® is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms.
• ORIC has offices in South San Francisco and San Diego, California.
• For more information, please go to www.oricpharma.com, and follow us on X or LinkedIn.

Equal Opportunity

• ORIC Pharmaceuticals, Inc. is an equal opportunity employer.
• ORIC does not discriminate based on race, color, religion, gender, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other legally protected characteristics.