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About the Role

This role offers an exciting opportunity to play a key part in advancing the understanding of macrophage and myeloid cell biology in fibrosis and cancer. You will combine expertise in primary human immune cells with cutting-edge cellular and functional assays to investigate macrophage heterogeneity, activation states, and immune-stromal interactions. The successful candidate will be a motivated experimental scientist contributing directly to discovery programmes, with significant scientific ownership and exposure to early drug discovery.

Responsibilities

Establish scalable workflows for processing human blood and leukopak samples, including PBMC isolation and generation of primary human macrophages.
Develop, optimise, and execute functional assays using primary and engineered immune cells, with a particular focus on macrophages and other myeloid cell populations.
Perform multi-colour and high-parameter flow cytometry for immune cell phenotyping and functional characterisation.
Design and execute macrophage activation, phagocytosis, cytokine secretion, and co-culture assays to investigate target biology and therapeutic activity.
Develop and apply approaches to understand macrophage heterogeneity and function within disease-relevant microenvironments.
Support the development of immune-stromal and ECM-based cellular models for target discovery and therapeutic screening.
Analyse, interpret, and communicate experimental findings to multidisciplinary project teams.
Contribute to the development of new macrophage and myeloid biology capabilities through implementation of innovative technologies, cellular models, and experimental approaches.
Maintain accurate laboratory records and support safe and efficient laboratory operations.

Requirements

Strong background in macrophage and myeloid cell biology.
Significant hands-on experience handling human blood samples, leukopak processing, PBMC isolation, and immune cell culture.
Experience deriving, characterising, and functionally evaluating primary human macrophages.
Strong experience with multi-colour and/or high-parameter flow cytometry, including immune phenotyping and data analysis.
Experience developing and executing immune cell-based functional assays.
Strong experimental, analytical, and problem-solving skills.
Excellent communication skills and ability to work effectively within multidisciplinary teams.
Experience in immuno-oncology, fibrosis, inflammation, or tissue remodelling research.
Experience with antibody-based therapeutics or immune-modulating agents.
Experience with stromal biology, extracellular matrix biology, or immune-stromal co-culture systems.
Experience with molecular biology techniques such as qPCR, RNA analysis, CRISPR-based perturbation, or gene knockdown approaches.
Previous experience in a biotechnology or pharmaceutical research environment.
Demonstrated ability to independently design, execute, troubleshoot, and interpret experiments.
Passion for hands-on laboratory research and scientific discovery.

Skills

Macrophage biology
Myeloid cell biology
Human blood sample handling
Leukopak processing
PBMC isolation
Immune cell culture
Primary human macrophage derivation and characterisation
Functional evaluation of immune cells
Multi-colour flow cytometry
High-parameter flow cytometry
Immune phenotyping
Flow cytometry data analysis
Immune cell-based functional assays
Experimental design
Analytical skills
Problem-solving
Communication
Teamwork
Immuno-oncology
Fibrosis research
Inflammation research
Tissue remodelling research
Antibody-based therapeutics
Immune-modulating agents
Stromal biology
Extracellular matrix biology
Immune-stromal co-culture systems
qPCR
RNA analysis
CRISPR-based perturbation
Gene knockdown
Biotechnology research
Pharmaceutical research

Location

White City, West London

Work Type

Full-time

Experience Level

2-4 years of relevant postdoctoral and/or industry experience

Education Level

PhD in Immunology, Cell Biology, Biomedical Sciences, Cancer Biology, or a related discipline

About the Company

Engitix Therapeutics is a pioneering biotechnology company unlocking extracellular matrix (ECM) biology to develop transformative therapeutics for fibrosis and oncology.
Engitix is a growing biotech company based in White City Place, West London.
We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform.
Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates.
Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.