Impress employers and recruiters.
Choose from hundreds of resume examples.

Target Resume Now

About the Role

We are seeking an exceptional Research Associate II or Senior Research Associate to join our In Vitro Pharmacology team. In this role, you will help advance CRISPR-based epigenetic therapies from discovery through preclinical development, with a focus on neuromuscular and rare genetic diseases. This position is ideal for a highly motivated scientist who enjoys hands-on experimentation, critical data analysis, and scientific problem-solving in a fast-paced biotechnology environment, with the opportunity to take increasing ownership of projects and grow into more independent scientific roles.

Responsibilities

Design, execute, analyze, and interpret in vitro pharmacology experiments that support therapeutic candidate discovery and advancement.
Develop and optimize cellular assays to evaluate CRISPR-based epigenetic editing systems, including potency, durability, specificity, and mechanism of action, to inform program decisions.
Generate high-quality datasets and apply rigorous analysis to support data-driven program decisions.
Partner closely with cross-functional teams to advance therapeutic programs.
Culture, engineer, and characterize mammalian cell lines, primary cells, and iPSC-derived disease models.
Perform molecular and cellular analyses including qPCR, RT-qPCR, digital PCR, Western blotting, ELISA, flow cytometry, immunofluorescence, and next-generation sequencing-based assays.
Evaluate delivery and activity of gene therapy modalities, including viral (AAV, Lenti) and non-viral delivery systems.
Maintain detailed experimental records and contribute to study reports, presentations, and regulatory documentation.
Stay current with emerging technologies and scientific advances in CRISPR, epigenetics, gene therapy, and neuromuscular disease research.

Requirements

B.S. or M.S. in Molecular Biology, Cell Biology, Genetics, Neuroscience, Biomedical Engineering, or related field.
3–5+ years of relevant industry experience (Research Associate II).
B.S. or M.S. with 5–8+ years of industry experience (Senior Research Associate).
Demonstrated ability to independently execute complex studies and contribute to experimental strategy.
Hands-on experience with CRISPR technologies, including CRISPR-Cas9, CRISPRi, CRISPRa, or epigenome editing platforms.
Strong molecular biology skills including nucleic acid extraction, PCR, qPCR, dPCR, cloning, and gene expression analysis.
Mammalian cell culture and cellular assay development experience.
Experience with viral vector systems (AAV, lentivirus, or related gene therapy platforms).
Proficiency in flow cytometry, immunofluorescence staining, microscopy, and protein expression analyses.
Strong data analysis, experimental design, and troubleshooting skills.
Experience in epigenetics, chromatin biology, transcriptional regulation, or gene expression control.
Experience working with neuromuscular diseases such as Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), FSHD, myotonic dystrophy, ALS, SMA, or related disorders.
Experience with myoblasts, human iPSC-derived skeletal muscle or other disease-relevant cellular models.
Familiarity with transcriptomics, NGS, ATAC-seq, ChIP-seq, or other genomic profiling technologies.
Prior experience supporting preclinical therapeutic development programs in biotechnology or pharmaceutical settings.
Knowledge of translational biomarkers and pharmacology assay development.

Skills

CRISPR technologies
CRISPR-Cas9
CRISPRi
CRISPRa
Epigenome editing
Molecular biology
Nucleic acid extraction
PCR
qPCR
dPCR
Cloning
Gene expression analysis
Mammalian cell culture
Cellular assay development
Viral vector systems
AAV
Lentivirus
Gene therapy platforms
Flow cytometry
Immunofluorescence staining
Microscopy
Protein expression analyses
Data analysis
Experimental design
Troubleshooting
Epigenetics
Chromatin biology
Transcriptional regulation
Gene expression control
Neuromuscular diseases
Duchenne muscular dystrophy (DMD)
Becker muscular dystrophy (BMD)
FSHD
Myotonic dystrophy
ALS
SMA
Myoblasts
Human iPSC-derived skeletal muscle
Transcriptomics
NGS
ATAC-seq
ChIP-seq
Genomic profiling technologies
Preclinical therapeutic development
Translational biomarkers
Pharmacology assay development
Scientific curiosity
Critical thinking
Attention to detail
Collaboration

Location

South San Francisco, CA

Work Type

Full-time

Experience Level

Research Associate II (3-5+ years)
Senior Research Associate (5-8+ years)

Education Level

B.S. or M.S.

Salary/Compensations

$95,000 to $115,000 USD annually

About the Company

Our company is based on the science of our founder, Stanley Qi, one of the original CRISPR co-inventors who then furthered the technology so that DNA does not need to be cut to accomplish gene regulation. Instead, we regulate the epigenome to suppress and activate multiple genes simultaneously. We are further evolving the platform and leveraging its strengths to address unmet medical needs.
We are looking for exceptional team members who want an active role in building a rapidly growing biotech.
Epicrispr Biotechnologies is an early-stage biotechnology company developing a novel technology platform that can provide safe and persistent control of targeted gene regulation. Our proprietary platform represents an entirely new class of therapeutics that can be leveraged to treat severe disease across numerous therapeutic areas, including complex diseases impacted by multiple genes.

Equal Opportunity

Epicrispr Biotechnologies provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.