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About the Role

The Translational PK/PD Scientific Director is an expert mathematical modeler and scientist who can lead the development of and supervise others in mechanistic modeling strategy for drug discovery, focusing on biologics, protein therapeutics, and peptides. This role specifically seeks an expert in physiologically-based pharmacokinetic (PBPK) modeling to design mechanistic models for translating findings across therapeutic modalities and species.

Responsibilities

Serve as expert PK/PD modeler in cross-functional teams to make model-informed decisions about drug discovery, modality selection, and dose prediction across therapeutic areas.
Integrate in vitro and in vivo data to build PBPK, quantitative systems pharmacology (QSP), or other mechanistic modeling platforms of drug disposition and pharmacology to support forward/reverse translation for established and novel therapeutic targets.
Guide software developers in designing automated workflows for implementing modeling platforms to inform human PK/PD and dose projections.
Collaborate across the PDMB organization to develop modeling and simulation strategies to identify and optimize drug candidates.
Provide scientific guidance and cross-functional supervision to a team of growing scientists.
Mentor and supervise junior colleagues to perform the above duties and grow capabilities.
Demonstrate outstanding leadership and communication skills, collaborating across departments to build strategies for quantitative model-informed drug discovery.

Requirements

Ph.D. in Pharmaceutics / Pharmaceutical Sciences, Pharmacokinetics, Pharmacology, Systems Pharmacology / Quantitative Pharmacology, Biomedical Engineering / Bioengineering, Chemical Engineering, Applied Mathematics / Mathematical Biology, Biostatistics / Statistics, Computational Biology / Systems Biology, Biophysics, Operations Research, Computer Science, Toxicology or equivalent with ≥ 7 years experience.
PharmD or equivalent with ≥ 9 years experience.
MS or equivalent with ≥ 11 years experience.
Experience means a record of increasing responsibility and independence in drug discovery/development within industry, academia, regulatory, or non-profit settings.
Experience performing hands-on translational PKPD and PBPK modeling using standard modeling software (e.g., Matlab / SimBiology, OSP Suite, Simcyp, Gastroplus, Monolix, R) for discovery/development of biologics, protein therapeutics, and/or peptides.
Expert skills in mathematical problem solving, critical data analysis/interpretation, experimental design, and statistics.
Demonstrated ability to lead interdisciplinary teams and oversee the work of other scientists and software developers.
Expertise in developing novel translational modeling strategies or automated workflows that rely on PBPK, QSP, or related mechanistic modeling.

Skills

Cross-Team Coordination
Data Modeling
Dose Response Modeling
Drug Discovery Process
MATLAB
PBPK Modeling
Pharmacology
Physiologically-Based Pharmacokinetic Modeling
PKPD Modeling
Stakeholder Relationship Management
Therapeutic Proteins

Location

Domestic/International

Work Type

Hybrid

Experience Level

Senior

Education Level

Ph.D.
PharmD
MS

Salary/Compensations

$190,800.00 - $300,300.00

Benefits

Medical, dental, vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays, vacation, and compassionate and sick days
Annual bonus and long-term incentive, if applicable

About the Company

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Equal Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.