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About the Role

Heartflow is seeking a Senior Software Engineer to lead its agentic AI platform. This role offers high ownership within a small team, focusing on the intersection of AI and FDA-regulated medical device software, with direct influence on internal software development practices. You will build the foundational infrastructure for other engineering teams and collaborate with AI researchers, clinical scientists, and leadership.

Responsibilities

Own and maintain the core AI platform infrastructure, including shared libraries, MCP tool integrations, and deployment pipelines for internal agentic systems.
Apply AI to accelerate the software development lifecycle by using LLMs to parse requirements, map them to modules, and auto-generate test cases.
Design and architect Human-in-the-Loop (HITL) workflows to ensure AI-generated outputs align with FDA requirements.
Build and evolve the knowledge retrieval architecture for multi-agent systems to find, reason over, and synthesize complex clinical and regulatory data.
Develop and maintain MCP host environments, client applications, and servers to securely connect AI systems with enterprise platforms like GitHub, Jira, Salesforce, and Slack.
Create automated evaluation harnesses, including LLM-as-a-judge pipelines integrated into CI/CD, to validate AI output quality and prevent regressions.
Build sophisticated agentic frameworks by combining foundation models with operational patterns like ReAct and Plan-and-Solve, managing agent memory via vector databases.
Develop internal developer tooling, APIs, sandboxes, and DX infrastructure to enable product engineers to integrate AI into their workflows.
Mentor teammates in agentic AI practices and act as a liaison between engineering, clinical, regulatory, and product stakeholders.

Requirements

Strong proficiency in Python and TypeScript for building end-to-end agentic applications.
Deep experience with FastAPI for backend development and ML model integration.
Proficiency in React (or similar modern frontend frameworks) for building agentic UIs and MCP clients.
Hands-on experience with AWS and Infrastructure as Code (Terraform).
Experience with Agile development methodologies and project management tools.
Deep understanding of LLM API integration (Anthropic Claude, OpenAI), prompt engineering, and RAG orchestration.
Production experience building deterministic tool integrations for non-deterministic LLMs using MCP server/client architecture.
Track record of moving beyond manual testing to automated CI/CD-integrated evaluation using platforms like Langfuse, Braintrust, or Promptfoo.
Experience with Docker, RESTful APIs, Git, and CI/CD pipelines for deploying agents at scale in secure, isolated environments.
Ability to communicate complex AI concepts clearly to diverse audiences.
Familiarity with data privacy requirements in healthcare settings (HIPAA, PHI handling).
Experience driving technical vision and leading architectural decisions; ability to mentor and lead other engineers.
Bachelor's degree in Computer Science, Engineering, or related discipline, or equivalent experience.
7+ years of relevant industry experience.

Skills

Python
TypeScript
FastAPI
React
AWS
Terraform
Agile methodologies
LLM API integration
Prompt engineering
RAG orchestration
MCP server/client architecture
CI/CD
Langfuse
Braintrust
Promptfoo
Docker
RESTful APIs
Git
HIPAA
PHI handling

Location

Remote

Work Type

Full-time

Experience Level

Senior
7+ years

Education Level

Bachelor's degree in Computer Science, Engineering, or related discipline, or equivalent experience.

About the Company

Heartflow is a medical technology company advancing the diagnosis and management of coronary artery disease, the #1 cause of death worldwide, using cutting-edge technology.
The flagship product is an AI-driven, non-invasive cardiac test called the Heartflow FFRCT Analysis.
Heartflow is the first AI-driven non-invasive integrated heart care solution across the CCTA pathway.
Heartflow is a publicly traded company (HTFL) that has received international recognition for exceptional strides in healthcare innovation.
The product is cleared for use in the US, UK, Europe, Japan and Canada, and has been used for more than 500,000 patients worldwide.
Heartflow builds AI that gives clinicians a personalized, precision 3D model of a patient's heart from a single CT scan.
To date, Heartflow has helped clinicians manage care for nearly 650,000 patients across more than 1,800 institutions worldwide.
Every line of code shipped has a real person on the other side of it.

Equal Opportunity

Heartflow is an equal opportunity employer.
We celebrate diversity and are committed to creating an inclusive environment for all employees.
We do not discriminate against any employee or applicant because of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
This policy applies to every aspect of employment at Heartflow, including recruitment, hiring, training, relocation, promotion, and termination.