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About the Role

We are seeking a highly motivated and innovative Associate Principal Scientist to join our Discovery Oncology team. The successful candidate will lead the conception, design, and execution of discovery-stage research programs, partnering with cross-functional teams to advance differentiated cancer therapies from target validation through early development.

Responsibilities

• Design, establish, and optimize in vitro and ex vivo assays to elucidate mechanisms of action and assess therapeutic potential.
• Make timely, data-driven decisions that balance innovation, risk, and experimental rigor.
• Communicate scientific strategy, rationale, and results clearly to internal teams and help build external scientific presence through publications, conference presentations, and collaboration.
• Drive ideation and early-stage discovery efforts to deliver competitive oncology programs, leveraging internal expertise and emerging technologies.

Requirements

• Ph.D. in Cancer Biology, Cell Biology, Pharmacology, Immunology, Biochemistry, or a related discipline with four (4) or more years of relevant oncology drug discovery experience.
• Deep expertise in tumor biology and immune oncology, including cancer genomics and oncogenic signaling.
• Broad technical expertise in molecular and cellular biology, biochemistry, and analytical methods.
• Extensive hands-on in vitro experience designing, executing, and analyzing multi-color flow cytometry and mechanistic cell-based assays (e.g., viability/cytotoxicity, cell cycle, signaling, and immune response readouts).
• Demonstrated ability to drive innovative research, evidenced by high-impact publications, patents, and/or successful advancement of discovery programs.
• Passionate, creative, and collaborative scientist committed to improving outcomes for people living with cancer.
• Excellent oral and written communication skills, a positive, team-oriented mindset, and strong leadership potential.
• Hands-on experience with different therapeutic modalities (e.g., small molecules, mAbs, ADCs and TCEs).
• Extensive hands-on experience designing, executing, and analyzing in vivo mouse model data to evaluate therapeutics.

Skills

• Biochemistry
• Cancer Cell Biology
• Cancer Research
• Cell Biology
• Immuno-Oncology
• In Vitro Biology
• In Vitro Research
• In Vitro Studies
• Molecular Biology
• Oncology
• Tumor Biology
• Multi-color flow cytometry
• Mechanistic cell-based assays
• Small molecules
• mAbs
• ADCs
• TCEs
• In vivo mouse model data analysis

Location

• South San Francisco

Work Type

• Domestic/International Relocation
• VISA Sponsorship

Experience Level

• Associate Principal Scientist
• Four (4) or more years of relevant oncology drug discovery experience

Education Level

• Ph.D. in Cancer Biology, Cell Biology, Pharmacology, Immunology, Biochemistry, or a related discipline

Salary/Compensations

• $159,600.00 - $251,200.00

Benefits

• Eligible for annual bonus and long-term incentive, if applicable.
• Comprehensive package of benefits including medical, dental, vision healthcare and other insurance benefits (for employee and family).
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

About the Company

• Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Equal Opportunity

• As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
• As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
• We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
• We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
• We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.