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About the Role
Neion Bio is seeking a talented scientist with expertise in synthetic biology and genome engineering for biomanufacturing. This role involves building tools and methodologies for in-vivo vertebrate genome engineering and developing workflows to manipulate large DNA fragments and genomes. You will collaborate with engineers and biologists to create disruptive protein production technologies.
Responsibilities
- Innovate and iterate on Neion Bio’s transgenic animal platform.
- Develop and improve methods for DNA assembly, integration, editing, and screening.
- Develop and validate novel vertebrate genetic engineering approaches.
- Assist in building and optimizing molecular and cellular tools for DNA/RNA delivery.
- Perform high-throughput screens of delivery tools (LNPs, VLPs, AAVs, lenti- and adenoviral vectors, electroporation, chemical transfection) in various biological systems.
- Characterize and quantify genome editing events using molecular assays.
- Analyze data, generate figures, and report results.
- Present findings at R&D meetings.
- Maintain a thorough electronic lab notebook.
- Maintain a clean and organized laboratory environment.
Requirements
- PhD/MS in synthetic biology, bioengineering, molecular biology, genetics or related field, or 3+ years hands-on expertise in genomic manipulation and cell biology.
- Understanding and extensive hands-on experience with current precision editing techniques, including design, optimization, and verification of edits made with CRISPR-Cas9/HDR and Prime Editing.
- Hands-on experience with recombinases and integrases, or other large construct integration methods.
- Experience with in-vivo delivery of large payloads for genomic integration.
- Experience with avian or mammalian cell culture, DNA/RNA transfection, bacterial culture, recombinant DNA cloning techniques, primer design and PCR, qPCR, gel electrophoresis, nucleic acid extraction and purification.
- Self-motivated, proactive, works well under pressure and deadlines, and is detail-oriented.
- Enthusiasm for learning new skills and taking on new responsibilities.
- Strong written and oral communication skills, as well as creative problem-solving skills.
- Strong emotional intelligence and passion for building relationships across all levels of an organization.
- Enjoys the fast-paced startup environment and teamwork.
Skills
- Synthetic biology
- Genome engineering
- In-vivo vertebrate genome engineering
- Large DNA fragment manipulation
- Large genome manipulation
- Protein production technologies
- In vivo delivery
- Multi-Kb transgene integration
- Large serine recombinases
- DNA assembly
- DNA integration
- DNA editing
- DNA screening
- Vertebrate genetic engineering
- Molecular tools for DNA/RNA delivery
- High-throughput screening
- LNPs
- VLPs
- AAVs
- Lenti- and adenoviral vectors
- Electroporation
- Chemical transfection
- Cell culture
- Organ explant culture
- Live embryo manipulation
- Animal model manipulation
- Genome editing event characterization
- Molecular assays
- Data analysis
- Figure generation
- Results reporting
- R&D meeting presentations
- Electronic lab notebook maintenance
- Laboratory organization
- Precision editing techniques
- CRISPR-Cas9/HDR
- Prime Editing
- Recombinases
- Integrases
- Large construct integration
- In-vivo delivery of large payloads
- Genomic integration
- Avian cell culture
- Mammalian cell culture
- DNA transfection
- RNA transfection
- Bacterial culture
- Recombinant DNA cloning
- Primer design
- PCR
- qPCR
- Gel electrophoresis
- Nucleic acid extraction
- Nucleic acid purification
- High throughput screening
- Automation methods
- Viral vector design
- Viral vector optimization
- Viral vector use
- -omics based analysis
- Gene therapy tool development
- Flow cytometry
- Immunostaining
- Fluorescent microscopy
- dPCR
- NGS library preparation
Experience Level
- 3+ years hands-on expertise in genomic manipulation and cell biology
Education Level
- PhD/MS in synthetic biology, bioengineering, molecular biology, genetics or related field
Salary/Compensations
- $110-150K
Benefits
- Health insurance
- Dental insurance
- Vision insurance
- 401(k)
- Bonus compensation
- Equity compensation
About the Company
- Neion Bio is harnessing nature’s best molecular factory, the chicken egg, to make medicine affordable, accessible, and resilient.
- Using cutting edge genetic engineering and stem cell technology, we create “living bioreactors”, which act as fully autonomous 3D biomolecular printers, operating on existing industrial-scale infrastructure.
- Our platform can rapidly and scalably produce almost any protein, provide national resilience to drug shortages and de-risk complex supply chains, and ultimately take advantage of novel biological environments to solve unmet medical needs.
- We are on a mission to reimagine the way in which complex biological molecules are produced to transform human health.
- At Neion Bio you will play a pivotal role in an early-stage, fast-growing company, working alongside leading scientists and entrepreneurs.
- You will have the opportunity to participate in the enormous potential upside while having a huge impact on the world.