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About the Role

Lakefront Biotherapeutics is seeking a collaborative Associate Director, Project Management to drive early development programs, with a focus on Phase I/II clinical development in autoimmune diseases. This hands-on matrix leadership role requires a practical PM who can create clarity, maintain momentum, and help teams translate strategy into integrated plans and timely execution.

Responsibilities

• Drive day-to-day project management planning and coordination for one or more early development programs, with primary emphasis on Phase I/II clinical development activities.
• Partner with Clinical Development, Clinical Operations, and functional leads to build and maintain integrated development plans, program timelines, milestone maps, critical path analyses, risk/issue logs, action trackers, and decision logs.
• Facilitate cross-functional program and study team meetings, including agenda-setting, pre-read coordination, decision capture, action follow-up, and escalation of key issues.
• Guide cross-functional teams through competing priorities and ambiguity by building trust, clarifying ownership, encouraging balanced input, and driving alignment around decisions and next steps.
• Coordinate with CMC, Research/Preclinical, Translational Medicine, Regulatory, Safety/Pharmacovigilance, Biometrics, Data Management, Quality, Finance, and external partners to ensure program plans are integrated and interdependencies are visible.
• Support clinical execution planning and governance activities, including study team coordination, vendor and CRO milestone tracking as appropriate, key deliverables, and readiness for internal decision points.
• Proactively identify risks, bottlenecks, and resource constraints; partner with the Sr. Director, Project Management and functional leaders on mitigation options and timely escalation.
• Prepare concise program updates, dashboards, and materials for leadership, governance, partnership, and board discussions as requested.
• Contribute to fit-for-purpose PM processes, templates, and tools that support a lean startup environment without adding unnecessary complexity.

Requirements

• Bachelor's degree in a relevant field such as Life Sciences, Biotechnology, Business Administration, or a related discipline.
• Advanced degree (Master's, PhD, PharmD, or MBA) is a plus but not required if relevant experience is present.
• 8+ years of biotechnology or pharmaceutical industry experience, including 5+ years in project/program management or closely related drug development roles.
• Hands-on experience supporting clinical development programs is required; early clinical development experience, including Phase I/II programs, is strongly preferred.
• Experience in autoimmune diseases is preferred.
• Demonstrated ability to lead and influence matrix teams without direct authority, with strong emotional intelligence, listening skills, facilitation, conflict resolution, and written/verbal communication skills.
• Proven ability to create alignment among diverse stakeholders, manage competing priorities, and keep teams focused on high-impact activities and timely decisions.
• Working knowledge of clinical development, clinical operations, and development governance, with the ability to understand and integrate cross-functional inputs into practical program plans.
• Cross-functional experience across CMC, Research/Preclinical, Translational Medicine, Regulatory, Safety/Pharmacovigilance, Biometrics/Data Management, Quality, Finance, and/or external partners is a plus.
• Background in biologics or antibody-based therapeutics is a plus.
• Comfortable operating in a fast-paced, early-stage company environment where priorities may evolve and processes must be appropriately scaled.
• Highly organized and detail-oriented, with the ability to balance rigorous project management discipline with pragmatic execution and team flexibility.
• Skillful in relevant project management tools and methodologies, such as Gantt charts, MS Project, PowerPoint, SharePoint, OnePager, Power BI, integrated portfolio management, and/or PPM platforms.
• Prior direct people management experience is helpful but not required; successful matrix leadership and team facilitation are essential.

Skills

• Emotional intelligence
• Structured communication
• Sound judgment
• Ability to guide teams
• Matrix leadership
• Problem-solving
• Gantt charts
• MS Project
• PowerPoint
• SharePoint
• OnePager
• Power BI
• Integrated portfolio management
• PPM platforms

Location

• Belgium
• United States

Work Type

• Full-time

Experience Level

• Associate Director
• 8+ years of experience
• 5+ years in project/program management

Education Level

• Bachelor's degree in Life Sciences, Biotechnology, Business Administration, or related discipline
• Advanced degree (Master's, PhD, PharmD, or MBA) is a plus

Salary/Compensations

• $180,000 – $200,000
• Eligible for performance bonus plan

Benefits

• Enticing compensation and benefits package
• Comprehensive and generous benefits and programs

About the Company

• Lakefront Biotherapeutics is a global biotech headquartered in Belgium and the United States, driven by a clear mission to deliver best-in-class medicines that transform patients’ lives.
• We accelerate breakthrough science and innovation in areas of high unmet need, with a primary focus on immunology and oncology.
• We are seeking pioneers, thought leaders, and rapid thinkers with an entrepreneurial spirit and no tolerance for the status quo.
• We seek collaborative innovators and unwavering idealists.
• We are in search of the best-in-class.
• Your passion, innovation, and drive will shape the future of life-improving medicines.
• We provide an enticing compensation and benefits package and a vibrant, dynamic work environment.
• Your journey with us promises growth and impact.

Equal Opportunity

• Lakefront Biotherapeutics is dedicated to ensuring equal employment opportunities.
• Our hiring decisions are based on merit, considering qualifications, skills, performance, and achievements.
• We strictly prohibit discrimination against any employee or job applicant based on personal characteristics that are unrelated to their job.