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About the Role

The Senior Scientist will join the Respiratory Biology Discovery group to contribute to target identification, translational biology, and mechanism-of-action studies for early discovery programs in chronic lung diseases. The role emphasizes applying human-relevant in vitro and ex vivo experimental systems, focusing on primary airway epithelial biology, immune-epithelial interactions, functional assays, and translational biomarkers to generate high-quality mechanistic datasets and support biomarker discovery.

Responsibilities

Design, execute, and interpret in vitro and ex vivo studies to support respiratory target validation and translational biology programs.
Develop and apply human-relevant experimental systems, including primary airway epithelial cultures, air-liquid interface (ALI) models, immune cell assays, and co-culture platforms.
Generate mechanistic and disease-relevant datasets using molecular, cellular, imaging, and biomarker-based approaches.
Apply imaging techniques, including immunohistochemistry (IHC), immunofluorescence (IF), and high-content imaging, with image-based analysis to interrogate epithelial and inflammatory biology.
Perform and interpret flow cytometry/FACS-based immune and cellular phenotyping studies.
Support translational biomarker discovery and validation using multiplex immunoassay platforms (e.g., Meso Scale Discovery, Luminex, Olink).
Conduct molecular and cellular biology assays, including cell culture, PBMC isolation, PCR/qPCR, nucleic acid extraction, protein detection, and functional cellular assays.
Characterize disease-relevant biological pathways in chronic lung diseases, including inflammatory, epithelial, fibrotic, and immune mechanisms.
Generate reproducible, high-quality datasets to inform project decisions, translational hypotheses, and program progression.
Communicate scientific findings effectively through presentations, data reviews, and written reports.
Collaborate closely across biology, pharmacology, DMPK, and translational/clinical functions within a matrixed discovery environment.

Requirements

Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. in biology, immunology, pharmacology, physiology, pulmonary biology or related discipline and relevant experience.
Demonstrated expertise in primary human cell culture systems, particularly airway epithelial biology and/or air-liquid interface (ALI) cultures.
Strong hands-on wet lab experience in molecular and cellular biology techniques.
Experience with flow cytometry/FACS and multiplex biomarker platforms (e.g., Meso Scale Discovery, Luminex, Olink, AlphaLISA).
Expertise in imaging-based approaches, including immunohistochemistry (IHC), immunofluorescence (IF), immunocytochemistry (ICC), histology, and image analysis.
Ability to independently design, execute, troubleshoot, and interpret experimental studies.
Solid understanding of respiratory disease biology, including inflammatory and epithelial mechanisms relevant to chronic lung diseases.
Strong written and verbal scientific communication skills with ability to present and discuss data in cross-functional settings.
Prior experience in respiratory drug discovery and translational research environments.
Experience with immune-epithelial co-culture systems and/or macrophage biology.
Familiarity with transcriptomic datasets, including bulk or single-cell RNA sequencing.
Experience with barrier function assays (TEER), live-cell imaging, or spatial biology approaches.
San Francisco Residents Only: Will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only: Will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.

Skills

Cell Cultures
Cell Culture Techniques
Cellular Biology Techniques
Ex Vivo
Flow Cytometry
Imaging Techniques
Immunohistochemistry (IHC)
Immunology
In Vitro Studies
Molecular Biology
Primary Cell Culture
Pulmonary Disease Research
Meso Scale Discovery
Luminex
Olink
AlphaLISA
Immunofluorescence (IF)
Immunocytochemistry (ICC)
Histology
Image Analysis
PBMC isolation
PCR/qPCR
Nucleic acid extraction
Protein detection
Functional cellular assays
Transcriptomic datasets
Bulk RNA sequencing
Single-cell RNA sequencing
Barrier function assays (TEER)
Live-cell imaging
Spatial biology approaches

Location

US and Puerto Rico Residents Only

Work Type

Regular
Domestic/International Relocation
VISA Sponsorship

Experience Level

Senior Scientist
7+ years (Bachelor's)
4+ years (Master's)

Education Level

Bachelor's Degree
Master's Degree
Ph.D.

Salary/Compensations

$131,400.00 - $206,800.00

Benefits

Annual bonus
Long-term incentive
Medical, dental, vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays, vacation, and compassionate and sick days

About the Company

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Equal Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
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