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About the Role

Lead functional area scientists and drug discovery programs within the Discovery Biologics Protein Engineering department. This Principal Scientist role involves leadership as a functional SME and project team lead, interfacing with multiple cross-site groups and therapeutic areas. The role is integral to helping the world meet new breakthroughs and make meaningful contributions to global medical advancement, fostering an inclusive environment.

Responsibilities

Use advanced antibody and protein engineering methods to design and optimize novel biotherapeutics.
Support molecular biology acceleration for complex molecular engineering.
Work closely with HT protein engineering and computational protein engineers to integrate augmented designs and computational approaches toward accelerated derisking and optimization of biologics.
Lead and participate in cross-functional biologics programs from discovery to IND, integrating early research through candidate nomination and selection.
Foster a high-performance culture of collaboration, engagement, self-accountability, and inclusion.

Requirements

PhD in Protein Engineering, Biochemistry, Biology, Biophysics, Biotechnology, Bioengineering, Immunology, Pharmaceutical Sciences, Chemistry, Computational Protein Design, or related STEM field with 8+ years of applied experience.
MS with 10+ years of applied experience.
BS with 14+ years of applied experience.
Demonstrated deep experience advancing protein therapeutics from discovery to development, preferably in immune cell engagers.
Established a strong external reputation through high-impact publications, presentations, and scientific community engagement.
Excellent verbal and written communication and collaboration abilities.

Skills

Expertise in functional optimization of biologics, especially immune cell engagers.
Knowledge in guiding advantageous molecular designs in a competitive landscape.
In-depth and current knowledge of antibody and protein therapeutics.
Proven skills in molecular biology and antibody and protein optimization/engineering approaches.
Expert-level hands-on experience in protein engineering across wet-lab and computation-based methods.
Strong technical knowledge of multiple aspects of biologics production including protein engineering, expression, purification, and characterization.
Project leadership experience across discovery stages, from target evaluation, hit identification through preclinical development of therapeutic candidates.
Prior direct people management, including demonstrated mentorship and a track record of talent development.
Track record of driving scientific or platform innovations.
Recognized team player with strong collaboration skills and openness.
Fostering a high-performance culture of collaboration, engagement, self-accountability, and inclusion.
Experience advancing protein therapeutics beyond traditional mAbs, including VHHs, multi-specifics, fusion proteins, and ADCs.
Antibody Engineering.
Antibody Therapeutics.
Biologics.
Mentorship.
People Management.
Protein Engineering.
T Cell Immunology.
Therapeutic Proteins.

Location

South San Francisco

Work Type

Full-time
Onsite

Experience Level

Principal Scientist
8+ years of applied experience (with PhD)
10+ years of applied experience (with MS)
14+ years of applied experience (with BS)

Education Level

PhD in Protein Engineering, Biochemistry, Biology, Biophysics, Biotechnology, Bioengineering, Immunology, Pharmaceutical Sciences, Chemistry, Computational Protein Design, or related STEM field
Master of Science (MS)
Bachelor of Science (BS)

Salary/Compensations

$176,200.00 - $277,300.00
Eligible for annual bonus and long-term incentive

Benefits

Comprehensive package of benefits
Medical insurance (for employee and family)
Dental insurance (for employee and family)
Vision healthcare insurance (for employee and family)
Other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation days
Compassionate days
Sick days

About the Company

A global health care leader with a diversified portfolio of prescription medicines, vaccines, and animal health products.
Legacy of over a century, fueled by innovation and inventiveness.
Success backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Embraces the value of bringing talented, committed people with diverse experiences, perspectives, skills, and backgrounds together.
Fosters breakthrough innovation when people with diverse ideas come together in an inclusive environment.
Encourages colleagues to respectfully challenge one another’s thinking and approach problems collectively for the common good.

Equal Opportunity

An equal opportunity employer, committed to fostering an inclusive workplace.
Committed to inclusion, ensuring candidates can engage in a hiring process that exhibits their true capabilities.
Provides equal opportunities to all employees and applicants for employment.
Prohibits discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, complies with all affirmative action requirements for protected veterans and individuals with disabilities.
Considers qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Considers for employment all qualified applicants, including those with criminal histories, consistent with applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.