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About the Role

This role is for a highly innovative and technically rigorous Scientist/Senior Scientist within the Cardiometabolic Disease (CMD) department at our company's Research Labs. The position requires deep expertise in preclinical in vivo models, particularly in cardiovascular and renal disease biology. The successful candidate will take hands-on ownership of complex rodent in vivo models and advanced physiological phenotyping to enable mechanistic discovery and target validation. Responsibilities include designing, executing, and interpreting sophisticated in vivo studies, often involving surgery, invasive measurements, and longitudinal functional readouts, directly influencing target selection and early translational strategy for cardio-renal programs. This role is ideal for a scientist deeply embedded in experimental execution, possessing strong physiological intuition, and thriving in a discovery environment where in vivo data drive scientific decisions.

Responsibilities

Independently design, establish, optimize, and execute pre‑clinical acute and chronic in vivo studies using animal models relevant to cardiovascular, renal, and metabolic diseases.
Conduct laboratory procedures including animal handling, dosing, blood collection, and tissue biopsy sampling.
Demonstrate strong understanding of anatomy and physiology, with experience in small‑animal surgical techniques, including survival and non‑survival procedures, with specialization in minipump implantation, telemetry implantation, and rodent vessel cannulation.
Perform non-invasive and invasive cardiovascular phenotyping, including echocardiography, and pressure–volume loop assessment.
Analyze, interpret, and report data generated from in vivo experiments.
Ensure experimental rigor, reproducibility, and appropriate study design (controls, powering, randomization, endpoints).
Initiate and execute hypothesis‑driven discovery studies that integrate in vivo functional endpoints with molecular, cellular, and biochemical readouts.
Partner with cross functional project teams and collaborators to advise on model selection, study design, and endpoint strategy and to translate in vivo findings into target validation, proof of mechanism, and proof of concept datasets.
Maintain rigorous documentation of experimental work using electronic lab notebooks.
Adhere to the highest standards of animal welfare, IACUC compliance, and laboratory best practices.
Participate in shared laboratory responsibilities and contribute to continuous improvement of in vivo capabilities.
Contribute to manuscripts, internal reports, and technical documentation.

Requirements

Extensive hands-on experience with rodent in vivo models, with a strong emphasis on cardiovascular and/or renal disease.
Demonstrated proficiency in survival surgeries and post‑operative care.
Demonstrated proficiency in cardiovascular phenotyping (e.g., echocardiography, invasive hemodynamics, telemetry).
Demonstrated proficiency in renal functional assessments (e.g., GFR, serum/urine biomarkers, metabolic cages).
Proven ability to design, execute, and interpret complex in vivo studies with minimal supervision.
Strong grounding in disease biology and physiological mechanisms relevant to cardio‑renal disorders.
Track record of scientific productivity, including peer‑reviewed publications and/or impactful internal deliverables.
Excellent written and verbal communication skills.
Ability to work effectively in team‑based research environments.

Skills

Cardiometabolic
Cardiovascular Diseases
Cardiovascular Surgery
In Vivo Animal Models
In Vivo Imaging
In Vivo Studies
Phenotyping
Survival Surgeries
PK/PD relationships
Translational biomarker strategies
In vitro or ex vivo assays
Industry or advanced discovery research setting experience

Location

South San Francisco

Work Type

Regular

Experience Level

7 years relevant experience with a Bachelor's degree
4 years relevant experience with a Master's degree
Relevant experience with a Ph.D.

Education Level

Bachelor's in Biology, Physiology, Pharmacology, Biomedical Sciences or a related discipline
Master's in Biology, Physiology, Pharmacology, Biomedical Sciences or a related discipline
Ph.D. in Biology, Physiology, Pharmacology, Biomedical Sciences or a related discipline

Salary/Compensations

$131,400.00 - $206,800.00

Benefits

Annual bonus (if applicable)
Long-term incentive (if applicable)
Medical healthcare benefits (for employee and family)
Dental healthcare benefits (for employee and family)
Vision healthcare benefits (for employee and family)
Other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation
Compassionate days
Sick days

About the Company

A global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.
Our legacy of over a century is fueled by the spark that drives innovation and inventiveness.
Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
We embrace the value of bringing together talented and committed people with diverse experiences, perspectives, skills, and backgrounds.
We believe breakthrough innovation occurs when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
We encourage colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Equal Opportunity

Committed to inclusion, ensuring candidates can engage in a hiring process that exhibits their true capabilities.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment.
We prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.